Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tyrosine kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | Janus kinase 3 | Starlite/ChEMBL | References |
Homo sapiens | Janus kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | Janus kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0015 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0015 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0015 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0015 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0015 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0015 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0015 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0015 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.5 | 0.5 | |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0015 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 12 nM | Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay | ChEMBL. | 26288682 |
IC50 (binding) | = 210 nM | Inhibition of JAK2 in human SET2 cells assessed as inhibition of cell proliferation after 72 hrs by [3H]-thymidine incorporation assay | ChEMBL. | 26288682 |
IC50 (binding) | = 220 nM | Inhibition of recombinant JAK1 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay | ChEMBL. | 26288682 |
IC50 (binding) | = 290 nM | Inhibition of recombinant Tyk2 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay | ChEMBL. | 26288682 |
IC50 (binding) | = 500 nM | Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay | ChEMBL. | 26288682 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.