Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hexosaminidase B (beta polypeptide) | References | |
Homo sapiens | hexosaminidase A (alpha polypeptide) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.0216 | 1 | 1 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0216 | 1 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Echinococcus multilocularis | beta hexosaminidase subunit alpha | 0.0135 | 0.5956 | 0.5956 |
Onchocerca volvulus | Hexosaminidase D homolog | 0.005 | 0.1724 | 0.5 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0216 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0001 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0135 | 0.5956 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0465 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0216 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0465 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1724 | 0.1724 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1681 | 0.1681 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1681 | 0.1681 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0216 | 1 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0465 | 1 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0216 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0465 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0465 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0465 | 0.0465 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0465 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0903 | 0.0903 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.005 | 0.1724 | 0.1724 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0135 | 0.5956 | 1 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0216 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1681 | 0.1681 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1681 | 0.1681 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0465 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0465 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0135 | 0.5956 | 1 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.005 | 0.1724 | 0.1724 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0216 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1724 | 0.1724 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0903 | 0.0903 |
Echinococcus granulosus | beta hexosaminidase subunit alpha | 0.0135 | 0.5956 | 0.5956 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0903 | 0.0903 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0216 | 1 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0135 | 0.5956 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0465 | 0.0465 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
FC (binding) | = 1.5 | Chaperoning efficacy at HexA alpha G269S mutant in ATSD patient fibroblasts assessed as maximum increase in enzyme activity using MUGS substrate incubated for 1 to 2 hrs by spectrofluorometry relative to control | ChEMBL. | 25984755 |
IC50 (binding) | = 18 uM | Inhibition of human placental HexA using pNPGlcNAc substrate | ChEMBL. | 25984755 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.