Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | beta-hexosaminidase B | 0.018 | 0.4049 | 0.6837 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0222 | 0.5922 | 1 |
Brugia malayi | hypothetical protein | 0.0105 | 0.068 | 0.1148 |
Chlamydia trachomatis | dihydrofolate reductase | 0.009 | 0 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0105 | 0.068 | 0.1148 |
Echinococcus multilocularis | beta hexosaminidase subunit alpha | 0.0113 | 0.1 | 0.1688 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.018 | 0.4049 | 0.6837 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0113 | 0.1 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0113 | 0.1 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0113 | 0.1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0222 | 0.5922 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.018 | 0.4049 | 0.5 |
Schistosoma mansoni | beta-hexosaminidase B | 0.018 | 0.4049 | 0.6837 |
Onchocerca volvulus | 0.0222 | 0.5922 | 0.5 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0222 | 0.5922 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0312 | 1 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.018 | 0.4049 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0222 | 0.5922 | 1 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0113 | 0.1 | 1 |
Echinococcus granulosus | beta hexosaminidase subunit alpha | 0.0113 | 0.1 | 0.1688 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.018 | 0.4049 | 0.6837 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0312 | 1 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.018 | 0.4049 | 0.6837 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0222 | 0.5922 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0222 | 0.5922 | 1 |
Brugia malayi | thymidylate synthase | 0.0222 | 0.5922 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0312 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0312 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0222 | 0.5922 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.018 | 0.4049 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0312 | 1 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.018 | 0.4049 | 0.5 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.018 | 0.4049 | 0.6837 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKb (functional) | < 6.8 | Antagonistic activity against human transient receptor potential vanilloid type 1 in FLIPR assay | ChEMBL. | 15203132 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.