Detailed information for compound 210669

Basic information

Technical information
  • TDR Targets ID: 210669
  • Name: N-[[1-(2-diethylaminoethylamino)-9-oxothioxan then-4-yl]methyl]ethanesulfonamide
  • MW: 447.614 | Formula: C22H29N3O3S2
  • H donors: 2 H acceptors: 3 LogP: 4.08 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNc1ccc(c2c1c(=O)c1c(s2)cccc1)CNS(=O)(=O)CC)CC
  • InChi: 1S/C22H29N3O3S2/c1-4-25(5-2)14-13-23-18-12-11-16(15-24-30(27,28)6-3)22-20(18)21(26)17-9-7-8-10-19(17)29-22/h7-12,23-24H,4-6,13-15H2,1-3H3
  • InChiKey: ULPJPHDJEDJIRL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[1-(2-diethylaminoethylamino)-9-oxo-thioxanthen-4-yl]methyl]ethanesulfonamide
  • N-[[1-(2-diethylaminoethylamino)-9-oxo-4-thioxanthenyl]methyl]ethanesulfonamide
  • N-[[1-(2-diethylaminoethylamino)-9-keto-thioxanthen-4-yl]methyl]ethanesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi neuropeptide F receptor 0.003 0.0475 0.0445
Brugia malayi follicle stimulating hormone receptor 0.003 0.0475 0.0445
Echinococcus multilocularis allatostatin A receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.1071 0.1043
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0475 0.2976
Brugia malayi BRM protein 0.0071 0.1542 0.1515
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0475 0.2976
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0144 0.08
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0475 0.2976
Brugia malayi Dopamine receptor protein 2 0.003 0.0475 0.0445
Echinococcus granulosus Chromo domain 0.0012 0.0032 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.0124 0.2886 1
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.0475 0.2976
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0475 0.2976
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Schistosoma mansoni opsin-like receptor 0.003 0.0475 0.2976
Brugia malayi AKH receptor 0.003 0.0475 0.0445
Schistosoma mansoni amine GPCR 0.003 0.0475 0.2976
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0401 1 1
Echinococcus granulosus g protein coupled receptor 0.003 0.0475 0.2976
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0401 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.0475 0.2976
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0032 0.0057
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0401 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0475 0.2976
Schistosoma mansoni hypothetical protein 0.0017 0.0144 0.08
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0475 0.2976
Echinococcus granulosus neuropeptide receptor A26 0.003 0.0475 0.2976
Loa Loa (eye worm) follicle stimulating hormone receptor 0.003 0.0475 0.0445
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0475 0.0445
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0475 0.2976
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0475 0.0445
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0475 0.2976
Loa Loa (eye worm) BRM protein 0.0037 0.066 0.063
Echinococcus multilocularis fmrfamide receptor 0.003 0.0475 0.2976
Brugia malayi hypothetical protein 0.003 0.0475 0.0445
Brugia malayi Serotonin receptor 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0475 0.2976
Schistosoma mansoni adenoreceptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus granulosus sex peptide receptor 0.003 0.0475 0.2976
Schistosoma mansoni histamine h1 receptor 0.003 0.0475 0.2976
Brugia malayi sulfakinin receptor protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0475 0.2976
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0475 0.2976
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0124 0.2886 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0475 0.2976
Brugia malayi hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Schistosoma mansoni neuropeptide receptor 0.003 0.0475 0.2976
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0475 0.2976
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.0053 0.1071 0.1043
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0144 0.08
Schistosoma mansoni hypothetical protein 0.0017 0.0144 0.08
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0475 0.0445
Echinococcus granulosus serotonin receptor 0.003 0.0475 0.2976
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0401 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.1071 0.1043
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0032 0.0057
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0475 0.2976
Echinococcus granulosus somatostatin receptor 0.003 0.0475 0.2976
Brugia malayi putative neuropeptide receptor 0.003 0.0475 0.0445
Schistosoma mansoni amine GPCR 0.003 0.0475 0.2976
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0012 0.0032 0.0057
Brugia malayi hypothetical protein 0.003 0.0475 0.0445
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0475 0.2976
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0475 0.2976
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0475 0.2976
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0475 0.0445
Brugia malayi G protein-coupled receptor 0.003 0.0475 0.0445
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0475 0.2976
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0475 0.0445
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0475 0.2976
Schistosoma mansoni opsin-like receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0475 0.2976
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0475 0.0445
Schistosoma mansoni hypothetical protein 0.0012 0.0032 0.0057
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0475 0.2976
Echinococcus multilocularis g protein coupled receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus multilocularis global transcription activator snf2l2 0.0071 0.1542 1
Brugia malayi hypothetical protein 0.0027 0.0401 0.037
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0401 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0401 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0475 0.2976
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0032 0.0057
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.0475 0.2976
Echinococcus granulosus neuropeptide receptor 0.003 0.0475 0.2976
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0475 0.2976
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0475 0.2976
Echinococcus granulosus BRK domain containing protein 0.0012 0.0032 0.0057
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0475 0.2976
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0013 0.0048 0.1204
Echinococcus multilocularis Chromo domain 0.0012 0.0032 0.0059
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0475 0.0445
Echinococcus multilocularis neuropeptide receptor 0.003 0.0475 0.2976
Echinococcus granulosus g protein coupled receptor 0.003 0.0475 0.2976
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0475 0.2976
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0475 0.0445
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) BRM protein 0.0045 0.0882 0.0853
Schistosoma mansoni hypothetical protein 0.0017 0.0144 0.08
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0475 0.2976
Schistosoma mansoni hypothetical protein 0.003 0.0475 0.2976
Schistosoma mansoni biogenic amine receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0475 0.2976
Echinococcus multilocularis serotonin receptor 0.003 0.0475 0.2976
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0475 0.0445
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0475 0.2976
Onchocerca volvulus 0.0401 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0475 0.0445
Schistosoma mansoni biogenic amine receptor 0.003 0.0475 0.2976
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0475 0.2976
Schistosoma mansoni amine GPCR 0.003 0.0475 0.2976
Brugia malayi ORL1-like opioid receptor 0.003 0.0475 0.0445
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0475 0.2976
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0475 0.2976
Brugia malayi hypothetical protein 0.003 0.0475 0.0445
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0642 0.0612
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0475 0.2976
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0032 0.0057
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0368 0.9169 0.8905
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0475 0.2976
Brugia malayi larval opioid receptor 0.003 0.0475 0.0445
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0475 0.0445
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.0017 0.0144 0.0113
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0401 1
Brugia malayi G-protein coupled receptor 0.003 0.0475 0.0445
Echinococcus granulosus orexin receptor type 2 0.003 0.0475 0.2976
Echinococcus granulosus g protein coupled receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Schistosoma mansoni hypothetical protein 0.0012 0.0032 0.0059
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.1071 0.1043
Echinococcus multilocularis fmrfamide receptor 0.003 0.0475 0.2976
Schistosoma mansoni amine GPCR 0.003 0.0475 0.2976
Schistosoma mansoni opsin-like receptor 0.003 0.0475 0.2976
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0401 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0475 0.2976
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0475 0.2976
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Brugia malayi neuropeptide F receptor 0.003 0.0475 0.0445
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0475 0.0445
Brugia malayi G-protein coupled receptor 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0475 0.2976
Brugia malayi Serotonin receptor 0.003 0.0475 0.0445
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0401 1 0.5
Brugia malayi Dopamine receptor 0.003 0.0475 0.0445
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0475 0.0445
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0475 0.2976
Schistosoma mansoni amine GPCR 0.003 0.0475 0.2976
Echinococcus granulosus g-protein coupled receptor 0.003 0.0475 0.2976
Echinococcus multilocularis orexin receptor type 2 0.003 0.0475 0.2976
Schistosoma mansoni hypothetical protein 0.003 0.0475 0.2976
Echinococcus granulosus global transcription activator snf2l2 0.0071 0.1542 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus granulosus GPCR family 2 0.0017 0.0144 0.08
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0475 0.2976
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0475 0.2976
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0475 0.0445
Echinococcus multilocularis g protein coupled receptor 0.003 0.0475 0.2976
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0124 0.2886 0.2851
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0401 1 1
Echinococcus multilocularis neuropeptide s receptor 0.003 0.0475 0.2976
Brugia malayi Dopamine receptor protein 1 0.003 0.0475 0.0445
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0475 0.2976
Schistosoma mansoni hypothetical protein 0.003 0.0475 0.2976
Echinococcus multilocularis sex peptide receptor 0.003 0.0475 0.2976
Trypanosoma cruzi hypothetical protein, conserved 0.0124 0.2886 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0475 0.2976
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0032 0.0057
Schistosoma mansoni neuropeptide receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0475 0.2976
Brugia malayi RE15519p 0.003 0.0475 0.0445
Echinococcus multilocularis GPCR, family 2 0.0017 0.0144 0.08
Brugia malayi hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Brugia malayi hypothetical protein 0.003 0.0475 0.0445
Echinococcus granulosus allatostatin A receptor 0.003 0.0475 0.2976
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0475 0.2976
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0475 0.2976
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0475 0.2976
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0475 0.2976
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0475 0.2976
Schistosoma mansoni helicase 0.0071 0.1542 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0475 0.2976
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0475 0.2976
Schistosoma mansoni hypothetical protein 0.003 0.0475 0.2976
Brugia malayi hypothetical protein 0.003 0.0475 0.0445
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0475 0.0445
Brugia malayi hypothetical protein 0.003 0.0475 0.0445
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0475 0.2976
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0475 0.2976
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0475 0.2976
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0475 0.2976
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0475 0.2976
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0124 0.2886 0.2851
Echinococcus multilocularis serotonin receptor 0.003 0.0475 0.2976
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0475 0.2976
Schistosoma mansoni neuropeptide receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0475 0.0445
Echinococcus multilocularis somatostatin receptor 0.003 0.0475 0.2976
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0475 0.2976
Leishmania major hypothetical protein, conserved 0.0124 0.2886 1
Schistosoma mansoni neuropeptide receptor 0.003 0.0475 0.2976
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0475 0.0445
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0475 0.2976
Schistosoma mansoni hypothetical protein 0.0017 0.0144 0.08
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0475 0.2976
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Brugia malayi GnHR receptor homolog 0.003 0.0475 0.0445
Brugia malayi hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0401 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0144 0.08
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.0027 0.0401 0.037
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0032 0.0057
Schistosoma mansoni myosin xvIII 0.003 0.0475 0.2976
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0144 0.0113
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0475 0.2976
Brugia malayi Melatonin receptor type 1A 0.003 0.0475 0.0445
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0277 0.683 0.5
Echinococcus granulosus fmrfamide receptor 0.003 0.0475 0.2976
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0401 1 1
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0475 0.2976
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.0475 0.2976
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0475 0.2976
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0475 0.2976
Schistosoma mansoni hypothetical protein 0.0036 0.0642 0.4077
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0401 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0475 0.2976
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0475 0.2976
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0475 0.2976
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0475 0.2976
Schistosoma mansoni biogenic amine receptor 0.003 0.0475 0.2976
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0475 0.2976
Echinococcus granulosus neuropeptide receptor 0.003 0.0475 0.2976
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0475 0.0445
Echinococcus granulosus neuropeptide s receptor 0.003 0.0475 0.2976
Echinococcus multilocularis g protein coupled receptor 0.003 0.0475 0.2976
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0144 0.08
Echinococcus multilocularis neuropeptide receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0144 0.0113
Loa Loa (eye worm) hypothetical protein 0.0036 0.0642 0.0612
Brugia malayi hypothetical protein 0.003 0.0475 0.0445
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0401 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0401 1
Brugia malayi hypothetical protein 0.0017 0.0158 0.0127
Echinococcus granulosus hypothetical protein 0.003 0.0475 0.2976
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0475 0.2976
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0144 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0475 0.0445
Echinococcus multilocularis BRK domain 0.0012 0.0032 0.0057

Activities

Activity type Activity value Assay description Source Reference
LCK (functional) = 3.7 The log cell kill of tumor-bearing mice, based on tumor growth delay. ChEMBL. 9733489
LTC (functional) = 0 The long term cures (LTC) value of the compound is the number of mice in a group with no palpable tumor. ChEMBL. 9733489
MTD (functional) = 203 mg kg-1 Maximum tolerated dose administrated iv (mg/kg) to mice ChEMBL. 9733489
MTD (functional) = 203 mg kg-1 Maximum tolerated dose administrated iv (mg/kg) to mice ChEMBL. 9733489
T/C (functional) = 0 % In vivo antitumor activity in mice implanted with murine pancreatic adenocarcinoma 03 ,T/C value(total/control) ChEMBL. 9733489
T/C (functional) = 0 % In vivo antitumor activity in mice implanted with murine pancreatic adenocarcinoma 03 ,T/C value(total/control) ChEMBL. 9733489

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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