Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0025 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0025 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0 | 0.5 |
Echinococcus granulosus | synaptic vesicle 2 protein | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | synaptic vesicle 2 protein | 0.0003 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0025 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0025 | 1 | 0.5 |
Treponema pallidum | mcbG protein | 0.0025 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.