Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0025 | 1 | 0.5 |
Echinococcus granulosus | synaptic vesicle 2 protein | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0025 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0025 | 1 | 0.5 |
Treponema pallidum | mcbG protein | 0.0025 | 1 | 0.5 |
Echinococcus multilocularis | synaptic vesicle 2 protein | 0.0003 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0025 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.