Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Potassium voltage-gated channel subfamily KQT member 4 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, KQT-like subfamily, member 3 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, KQT-like subfamily, member 5 | References | |
Homo sapiens | potassium voltage-gated channel, KQT-like subfamily, member 4 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, KQT-like subfamily, member 2 | References | |
Rattus norvegicus | Potassium voltage-gated channel subfamily KQT member 2/member 3 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania mexicana | hypothetical protein, conserved | Potassium voltage-gated channel subfamily KQT member 4 | 168 aa | 137 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.1291 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.1291 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.1291 | 1 | 0.5 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.1275 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 84 % | Activation of human Kv7.1/KCNE1 expressed in CHOK1 cells assessed as increase in current amplitude relative to control | ChEMBL. | 25987375 |
Activity (binding) | = 161 % | Activation of rat Kv7.4 expressed in CHOK1 cells assessed as increase in current amplitude relative to control | ChEMBL. | 25987375 |
Activity (binding) | = 163 % | Activation of human Kv7.4 expressed in CHOK1 cells assessed as increase in current amplitude relative to control | ChEMBL. | 25987375 |
Activity (binding) | = 237 % | Activation of rat Kv7.2/7.3 expressed in CHOK1 cells assessed as increase in current amplitude relative to control | ChEMBL. | 25987375 |
Activity (binding) | = 246 % | Activation of human Kv7.3/7.5 expressed in CHOK1 cells assessed as increase in current amplitude relative to control | ChEMBL. | 25987375 |
Activity (binding) | = 265 % | Activation of human Kv7.2/7.3 expressed in CHOK1 cells assessed as increase in current amplitude relative to control | ChEMBL. | 25987375 |
CL (ADMET) | = 15.6 ml/min.kg | Intrinsic clearance in human liver microsomes measured over 1 hr in presence of NADPH regenerating system | ChEMBL. | 25987375 |
EC50 (binding) | = 294 nM | Activation of rat Kv7.2/7.3 expressed in CHOK1 cells | ChEMBL. | 25987375 |
EC50 (binding) | = 334 nM | Activation of human Kv7.2/7.3 expressed in CHOK1 cells | ChEMBL. | 25987375 |
EC50 (binding) | = 376 nM | Activation of rat Kv7.4 expressed in CHOK1 cells | ChEMBL. | 25987375 |
EC50 (binding) | = 588 nM | Activation of human Kv7.3/7.5 expressed in CHOK1 cells | ChEMBL. | 25987375 |
EC50 (binding) | = 625 nM | Activation of human Kv7.4 expressed in CHOK1 cells | ChEMBL. | 25987375 |
EC50 (binding) | > 100000 nM | Activation of human Kv7.1/KCNE1 expressed in CHOK1 cells | ChEMBL. | 25987375 |
max activation (binding) | = 147 % | Activation of human Kv7.2/7.3 expressed in CHOK1 cells | ChEMBL. | 25987375 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.