Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phospholipase A2, group IB (pancreas) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Phospholipase A2 homolog | Get druggable targets OG5_134661 | All targets in OG5_134661 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134661 | All targets in OG5_134661 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0194 | 0.0671 | 0.0645 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.0671 | 0.6837 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0464 | 0.3287 | 0.4048 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0225 | 0.0968 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0317 | 0.1856 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0225 | 0.0968 | 0.1192 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0317 | 0.1856 | 0.5 |
Echinococcus granulosus | adam 17 protease | 0.0219 | 0.091 | 0.1121 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0284 | 0.1541 | 0.1518 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0317 | 0.1856 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0225 | 0.0968 | 0.1192 |
Onchocerca volvulus | 0.0181 | 0.0544 | 0.1334 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0225 | 0.0968 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0464 | 0.3287 | 0.4048 |
Loa Loa (eye worm) | hypothetical protein | 0.1158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0528 | 0.3901 | 0.3884 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.0544 | 0.5492 |
Brugia malayi | Matrixin family protein | 0.0309 | 0.1781 | 0.1758 |
Brugia malayi | thymidylate synthase | 0.0225 | 0.0968 | 0.0944 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0297 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 0.284 | 0.2821 |
Echinococcus multilocularis | adam 17 protease | 0.0199 | 0.0718 | 0.0884 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0283 | 0.1533 | 0.3888 |
Onchocerca volvulus | Matrilysin homolog | 0.0283 | 0.1533 | 0.3888 |
Onchocerca volvulus | 0.0225 | 0.0968 | 0.2429 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0284 | 0.1541 | 0.1518 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.0671 | 0.0645 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0317 | 0.1856 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0156 | 0.0297 | 0.027 |
Loa Loa (eye worm) | matrixin family protein | 0.0309 | 0.1781 | 0.1758 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0199 | 0.0718 | 0.7339 |
Brugia malayi | Hemopexin family protein | 0.0181 | 0.0544 | 0.0518 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0528 | 0.3901 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0964 | 0.812 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0317 | 0.1856 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0317 | 0.1856 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0283 | 0.1533 | 0.151 |
Loa Loa (eye worm) | thymidylate synthase | 0.0225 | 0.0968 | 0.0944 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0225 | 0.0968 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0225 | 0.0968 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0964 | 0.812 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.021 uM | Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay. | ChEMBL. | 8809154 |
IC50 (binding) | = 0.021 uM | Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay. | ChEMBL. | 8809154 |
IC50 (binding) | = 0.03 uM | Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC). | ChEMBL. | 8809154 |
IC50 (binding) | = 0.03 uM | Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC). | ChEMBL. | 8809154 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.