Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.917 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2975 | 0 | 0.5 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.917 | 1 | 1 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.917 | 1 | 1 |
Toxoplasma gondii | MAPEG family protein | 0.917 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
F (ADMET) | = 1.74 % | Bioavailability by the ratios of 14C p.o. /14C i.v. accumulated in bone at 24 hr (dose 10 mg/kg p.o.) | ChEMBL. | 11020278 |
F (ADMET) | = 3.1 % | Bioavailability by the ratios of 14C p.o. /14C i.v. accumulated in urine at 24 hr (dose 10 mg/kg p.o.) | ChEMBL. | 11020278 |
Permeability (ADMET) | = 0.00000016 cm s-1 | Basolateral to apical fluxes of the compound across Caco-2 cell monolayers at 37 degree celsius was studied. | ChEMBL. | 11020278 |
Permeability (ADMET) | = 0.00000023 cm s-1 | Apical to basolateral fluxes of the compound across Caco-2 cell monolayers at 37 degree celsius was studied. | ChEMBL. | 11020278 |
Permeability (ADMET) | = 0.00000055 cm s-1 | Basolateral to apical fluxes of the compound across Caco-2 cell monolayers at 37 degree celsius was studied. | ChEMBL. | 11020278 |
Permeability (ADMET) | = 0.00000103 cm s-1 | Apical to basolateral fluxes of the compound across Caco-2 cell monolayers at 37 degree celsius was studied. | ChEMBL. | 11020278 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.