Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | 6-phosphofructokinase | 0.0123 | 0.1474 | 0.9705 |
Loa Loa (eye worm) | phosphofructokinase | 0.0123 | 0.1474 | 0.9705 |
Brugia malayi | Cell death protein 3 precursor | 0.0125 | 0.1519 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0433 | 0.285 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0033 | 0.007 | 0.0477 |
Brugia malayi | phosphofructokinase | 0.0123 | 0.1474 | 0.9705 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0123 | 0.1474 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0033 | 0.007 | 0.0477 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0125 | 0.1519 | 1 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0123 | 0.1474 | 0.1474 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0154 | 0.1012 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0123 | 0.1474 | 0.9705 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0123 | 0.1474 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0123 | 0.1474 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.1519 | 1 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0033 | 0.007 | 1 |
Brugia malayi | hypothetical protein | 0.0125 | 0.1519 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0033 | 0.007 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0125 | 0.1519 | 1 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0033 | 0.007 | 1 |
Onchocerca volvulus | 0.0125 | 0.1519 | 1 | |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0033 | 0.007 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0033 | 0.007 | 0.0477 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0123 | 0.1474 | 1 |
Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.0033 | 0.007 | 0.0477 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0033 | 0.007 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0123 | 0.1474 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1519 | 1 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0123 | 0.1474 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0123 | 0.1474 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0123 | 0.1474 | 0.9705 |
Echinococcus multilocularis | caspase 2 | 0.0125 | 0.1519 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0033 | 0.007 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0123 | 0.1474 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 0.1051 | 0.6919 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0033 | 0.007 | 1 |
Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0029 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0096 | 0.1051 | 0.1051 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0433 | 0.285 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0123 | 0.1474 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0123 | 0.1474 | 0.9705 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0123 | 0.1474 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0033 | 0.007 | 0.0477 |
Trypanosoma brucei | pteridine reductase 1 | 0.0666 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.1106 | 0.7283 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0154 | 0.1012 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0123 | 0.1474 | 0.9705 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0125 | 0.1519 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0123 | 0.1474 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0154 | 0.1012 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0033 | 0.007 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0033 | 0.007 | 0.0477 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0033 | 0.007 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0433 | 0.285 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0033 | 0.007 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0029 | 0 | 0.5 |
Echinococcus granulosus | caspase 2 | 0.0125 | 0.1519 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1519 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0033 | 0.007 | 0.0477 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0123 | 0.1474 | 0.1474 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0125 | 0.1519 | 1 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0123 | 0.1474 | 0.9705 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0123 | 0.1474 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0123 | 0.1474 | 0.9705 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0033 | 0.007 | 0.0477 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0433 | 0.285 |
Brugia malayi | 6-phosphofructokinase | 0.0123 | 0.1474 | 0.9705 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.2 uM | Tested in vitro for cytotoxicity against human tumor cell line MCF-7/ADR (breast) | ChEMBL. | 10714502 |
GI50 (functional) | = 0.2 uM | Tested in vitro for cytotoxicity against human tumor cell line MCF-7/ADR (breast) | ChEMBL. | 10714502 |
GI50 (functional) | = 0.25 uM | Tested in vitro for cytotoxicity against human tumor cell line ACHN (renal). | ChEMBL. | 10714502 |
GI50 (functional) | = 0.25 uM | Tested in vitro for cytotoxicity against human tumor cell line ACHN (renal). | ChEMBL. | 10714502 |
GI50 (functional) | = 0.31 uM | Tested in vitro for cytotoxicity against human tumor cell line SF-268 (CNS). | ChEMBL. | 10714502 |
GI50 (functional) | = 0.31 uM | Tested in vitro for cytotoxicity against human tumor cell line SF-268 (CNS). | ChEMBL. | 10714502 |
GI50 (functional) | = 0.36 uM | Tested in vitro for cytotoxicity against human tumor cell line HOP62 (lung) | ChEMBL. | 10714502 |
GI50 (functional) | = 0.36 uM | Tested in vitro for cytotoxicity against human tumor cell line HOP62 (lung) | ChEMBL. | 10714502 |
GI50 (functional) | = 0.4 uM | Tested in vitro for cytotoxicity against human tumor cell line UACC 62 (melanoma) | ChEMBL. | 10714502 |
GI50 (functional) | = 0.4 uM | Tested in vitro for cytotoxicity against human tumor cell line UACC 62 (melanoma) | ChEMBL. | 10714502 |
GI50 (functional) | = 0.63 uM | Tested in vitro for cytotoxicity against human tumor cell line DU-145 (prostate) | ChEMBL. | 10714502 |
GI50 (functional) | = 0.63 uM | Tested in vitro for cytotoxicity against human tumor cell line DU-145 (prostate) | ChEMBL. | 10714502 |
GI50 (functional) | = 0.74 uM | Tested in vitro for cytotoxicity against human tumor cell line OVCAR8 (ovarian). | ChEMBL. | 10714502 |
GI50 (functional) | = 0.74 uM | Tested in vitro for cytotoxicity against human tumor cell line OVCAR8 (ovarian). | ChEMBL. | 10714502 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.