Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen, liver | References | |
Oryctolagus cuniculus | Glycogen phosphorylase, muscle form | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Glycogen phosphorylase, muscle form | 843 aa | 840 aa | 70.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glycogen phosphorylase | 0.0261 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0261 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0261 | 0.5 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0261 | 0.5 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0261 | 0.5 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0261 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0261 | 0.5 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0261 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0261 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0261 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0261 | 0.5 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0261 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0261 | 0.5 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0261 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0261 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0261 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Competitive inhibition of rabbit muscle glycogen phosphorylase-a assessed as release of inorganic phosphate from using varying levels of glucose-1-phosphate and constant concentration of AMP and glycogen measured after 1 min by Lineweaver-Burk plot method | LITERATURE. | 27522507 | |
Inhibition (binding) | Competitive inhibition of His6-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) assessed as release of inorganic phosphate using varying levels of glucose-1-phosphate and constant concentration of AMP and glycogen measured after 1 min by Lineweaver-Burk plot method | LITERATURE. | 27522507 | |
Ki (binding) | = 0.026 uM | Competitive inhibition of His6-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) assessed as release of inorganic phosphate using varying levels of glucose-1-phosphate and constant concentration of AMP and glycogen measured after 1 min by Dixon plot method | LITERATURE. | 27522507 |
Ki (binding) | = 0.031 uM | Competitive inhibition of rabbit muscle glycogen phosphorylase-b using alpha-D-glucose-1-phosphate as substrate by Dixon plot analysis | ChEMBL. | 26713107 |
Ki (binding) | = 0.065 uM | Competitive inhibition of rabbit muscle glycogen phosphorylase-a assessed as release of inorganic phosphate using varying levels of glucose-1-phosphate and constant concentration of AMP and glycogen measured after 1 min by Dixon plot method | LITERATURE. | 27522507 |
Ratio Ki (binding) | = 164600 | Potency index, ratio of alpha-D-glucose Ki to compound Ki for His6-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) | LITERATURE. | 27522507 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.