Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.7248 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1893 | 0.1893 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7248 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.7248 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.7248 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7248 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7248 | 1 |
Schistosoma mansoni | kinase | 0.0058 | 0.1672 | 0.1787 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.7248 | 0.5 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0135 | 0.9359 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0142 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1893 | 0.1893 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1893 | 0.1893 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.7248 | 0.7744 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7248 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.7248 | 0.7248 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0142 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7248 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.7248 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1893 | 0.1893 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.7248 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7248 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.7248 | 0.7248 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.7248 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7248 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 512 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 35218 after 16 to 20 hrs by broth microdilution method | ChEMBL. | 27040660 |
MIC (functional) | > 512 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 16 to 20 hrs by broth microdilution method | ChEMBL. | 27040660 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.