Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 10 (sodium/bile acid cotransporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0908 | 0.3503 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.2592 | 0.2592 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.2592 | 1 |
Brugia malayi | Sodium Bile acid symporter family protein | 0.0247 | 0.2592 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.0147 | 0.137 | 0.5288 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.01 | 0.0801 | 0.3091 |
Onchocerca volvulus | 0.025 | 0.2624 | 1 | |
Brugia malayi | Pre-SET motif family protein | 0.022 | 0.2254 | 0.8698 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.2592 | 0.2592 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0488 | 0.1881 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0075 | 0.0488 | 0.1881 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.2592 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0488 | 0.1881 |
Trichomonas vaginalis | set domain proteins, putative | 0.025 | 0.2624 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.2592 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.2592 | 0.2592 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.022 | 0.2254 | 0.8698 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0247 | 0.2592 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0109 | 0.0908 | 0.3503 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.2592 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0109 | 0.0908 | 0.3503 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0109 | 0.0908 | 0.3503 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 690 nM | In vitro inhibitory activity against uptake of [14C]-taurocholate in baby hamster kidney cells transfected with cDNA from human Apical Sodium-Codependent Bile Acid Transporter | ChEMBL. | 14552767 |
IC50 (binding) | = 690 nM | In vitro inhibitory activity against uptake of [14C]-taurocholate in baby hamster kidney cells transfected with cDNA from human Apical Sodium-Codependent Bile Acid Transporter | ChEMBL. | 14552767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.