Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic, kainate | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.0113 | 0.2966 | 0.3279 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0113 | 0.2966 | 0.3279 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | glutamate receptor 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Brugia malayi | Glutamate receptor 2 precursor | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.1376 | 0.1521 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0087 | 0.0635 | 0.0702 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.008 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.1376 | 0.1521 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0182 | 0.9045 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0098 | 0.159 | 0.1758 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.008 | 0 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0182 | 0.9045 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 uM | Binding affinity was determined against ionotropic glutamate receptor AMPA in rat brain synaptic membranes using [3H]-AMPA as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | = 1.1 uM | Binding affinity was determined against ionotropic glutamate receptor AMPA in rat brain synaptic membranes using [3H]-AMPA as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | = 6.4 uM | Binding affinity for the ionotropic glutamate receptor kainate in rat brain synaptic membranes using [3H]-kainate as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | = 6.4 uM | Binding affinity for the ionotropic glutamate receptor kainate in rat brain synaptic membranes using [3H]-kainate as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | > 10 uM | Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]-Glycine as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | > 10 uM | Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]-Glycine as radioligand | ChEMBL. | 7562904 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.