Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin-endoperoxide synthase 2 | No references | |
Mus musculus | prostaglandin-endoperoxide synthase 1 | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Blistered cuticle protein 3 | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0079 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.5 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0079 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0079 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 ug ml-1 | Inhibition of COX2 in C57BL/6 mouse peritoneal macrophages assessed as reduction in PGE2 formation pre-incubated for 2 hrs before LPS stimulation for 16 hrs followed by arachidonic acid addition and measured after 10 mins in presence of 500 uM aspirin by radio-immuno assay or enzyme-immunoassay | PATENT. | No reference |
IC50 (binding) | = 3 ug ml-1 | Inhibition of COX1 in C57BL/6 mouse peritoneal macrophages assessed as reduction in PGE2 formation pre-incubated for 2 hrs followed by arachidonic acid addition and measured after 10 mins by radio-immuno assay or enzyme-immunoassay | PATENT. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.