Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate receptor ionotropic, kainate | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Brugia malayi | Glutamate receptor 2 precursor | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0113 | 0.2966 | 0.3279 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0113 | 0.2966 | 0.3279 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | glutamate receptor 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.1376 | 0.1521 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0182 | 0.9045 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0098 | 0.159 | 0.1758 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.008 | 0 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0182 | 0.9045 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.1376 | 0.1521 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0087 | 0.0635 | 0.0702 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.008 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.9 uM | Binding affinity for the ionotropic glutamate receptor kainate in rat brain synaptic membranes using [3H]-kainate as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | = 2.9 uM | Binding affinity for the ionotropic glutamate receptor kainate in rat brain synaptic membranes using [3H]-kainate as radioligand | ChEMBL. | 7562904 |
IC50 (functional) | > 30 uM | Concentration of compound that inhibits by 50% LDH released by 24 hr application of 100 uM AMPA | ChEMBL. | 7562904 |
IC50 (functional) | > 30 uM | Concentration of compound that inhibits by 50% LDH released by 24 hr application of 500 uM kainate | ChEMBL. | 7562904 |
IC50 (functional) | > 30 uM | Concentration of compound that inhibits by 50% depolarizations induced by 10 uM AMPA | ChEMBL. | 7562904 |
IC50 (functional) | > 30 uM | Antagonistic activity against Ionotropic glutamate receptor AMPA induced LDH release in cultured rat cortical neurons after 24 hr 100 uM AMPA | ChEMBL. | 7562904 |
IC50 (functional) | > 30 uM | Antagonistic activity against Ionotropic glutamate receptor kainate induced LDH release in cultured cortical neurons in rat after 24 hr application of 500 uM of kainate | ChEMBL. | 7562904 |
IC50 (binding) | > 30 uM | Inhibition of Ionotropic glutamate receptor AMPA induced depolarization in rat cortical wedge by application of 10 uM of AMPA | ChEMBL. | 7562904 |
IC50 (functional) | > 30 uM | Antagonistic activity against Ionotropic glutamate receptor AMPA induced LDH release in cultured rat cortical neurons after 24 hr 100 uM AMPA | ChEMBL. | 7562904 |
IC50 (functional) | > 30 uM | Antagonistic activity against Ionotropic glutamate receptor kainate induced LDH release in cultured cortical neurons in rat after 24 hr application of 500 uM of kainate | ChEMBL. | 7562904 |
IC50 (binding) | > 30 uM | Inhibition of Ionotropic glutamate receptor AMPA induced depolarization in rat cortical wedge by application of 10 uM of AMPA | ChEMBL. | 7562904 |
IC50 (binding) | > 100 uM | Binding affinity was determined against ionotropic glutamate receptor AMPA in rat brain synaptic membranes using [3H]-AMPA as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | > 100 uM | Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]-Glycine as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | > 100 uM | Binding affinity was determined against ionotropic glutamate receptor AMPA in rat brain synaptic membranes using [3H]-AMPA as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | > 100 uM | Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]-Glycine as radioligand | ChEMBL. | 7562904 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.