Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1195 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1195 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.1195 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 1 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0071 | 1 | 1 |
Onchocerca volvulus | 0.0071 | 1 | 1 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1195 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.1195 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 6 mg kg-1 | compound was tested against Staphylococcus aureus UC9213 the vancomycin administered (sc) in mouse positive control expressed as ED50 values. | ChEMBL. | 9733498 |
ED50 (functional) | = 6 mg kg-1 | compound was tested against Staphylococcus aureus UC9213 the vancomycin administered (sc) in mouse positive control expressed as ED50 values. | ChEMBL. | 9733498 |
ED50 (functional) | = 11.2 mg kg-1 | Compound was tested against Staphylococcus aureus UC9213 after po administration in mouse | ChEMBL. | 9733498 |
ED50 (functional) | = 11.2 mg kg-1 | Compound was tested against Staphylococcus aureus UC9213 after po administration in mouse | ChEMBL. | 9733498 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration Streptococcus pneumoniae UC9912 | ChEMBL. | 9733498 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration against Staphylococcus epidermis UC12084 | ChEMBL. | 9733498 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration against Staphylococcus aureus UC6685 | ChEMBL. | 9733498 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration against Enterococcus faecalis UC9217 | ChEMBL. | 9733498 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration against Staphylococcus aureus UC9213 | ChEMBL. | 9733498 |
Pe (functional) | = 28 10e-6 cm s-1 | Permeability coefficient was measured in the presence of GST-inhibitor ethacrynic acid | ChEMBL. | 9733498 |
Pe (functional) | = 28 10e-6 cm s-1 | Permeability coefficient was measured in the presence of GST-inhibitor ethacrynic acid | ChEMBL. | 9733498 |
Pe (functional) | = 31 10e-6 cm s-1 | Permeability coefficient was measured in the absence of GST-inhibitor ethacrynic acid | ChEMBL. | 9733498 |
Pe (functional) | = 31 10e-6 cm s-1 | Permeability coefficient was measured in the absence of GST-inhibitor ethacrynic acid | ChEMBL. | 9733498 |
[A] (functional) | = 37 uM | permeability assessment across a monolayer of caco-2 cells in presence of GSH in aqueous base. | ChEMBL. | 9733498 |
[A] (functional) | = 37 uM | permeability assessment across a monolayer of caco-2 cells in absence of GSH in aqueous base. | ChEMBL. | 9733498 |
[A] (functional) | = 37 uM | permeability assessment across a monolayer of caco-2 cells in presence of GSH in aqueous base. | ChEMBL. | 9733498 |
[A] (functional) | = 37 uM | permeability assessment across a monolayer of caco-2 cells in absence of GSH in aqueous base. | ChEMBL. | 9733498 |
[EA] (functional) | = 0 uM | permeability assessment across a monolayer of caco-2 cells in presence of GST-inhibitor ethacrynic acid | ChEMBL. | 9733498 |
[EA] (functional) | = 0 uM | permeability assessment across a monolayer of caco-2 cells in presence of GST-inhibitor ethacrynic acid | ChEMBL. | 9733498 |
[EA] (functional) | = 50 uM | permeability assessment across a monolayer of caco-2 cells in absence of GST-inhibitor ethacrynic acid | ChEMBL. | 9733498 |
[EA] (functional) | = 50 uM | permeability assessment across a monolayer of caco-2 cells in absence of GST-inhibitor ethacrynic acid | ChEMBL. | 9733498 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.