Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0723 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0121 | 0.0573 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0121 | 0.0573 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0723 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.572 | 0.5653 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0723 | 1 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0121 | 0.0573 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0723 | 1 | 1 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.045 | 0.572 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.4461 | 0.4374 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | ~ 150 % | TNF-alpha stimulatory activity of the compound in B78/TNF/9 melanoma cells evaluated by ELISA method | ChEMBL. | 11354376 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.