Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic, kainate | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutamate receptor 2 | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0087 | 0.0635 | 0.0702 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.1376 | 0.1521 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0182 | 0.9045 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.008 | 0 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0182 | 0.9045 | 1 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.1376 | 0.1521 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | glutamate receptor 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0113 | 0.2966 | 0.3279 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0113 | 0.2966 | 0.3279 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Brugia malayi | Glutamate receptor 2 precursor | 0.008 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.68 uM | Binding affinity for the ionotropic glutamate receptor kainate in rat brain synaptic membranes using [3H]-kainate as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | = 0.68 uM | Binding affinity for the ionotropic glutamate receptor kainate in rat brain synaptic membranes using [3H]-kainate as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | = 9.7 uM | Binding affinity was determined against ionotropic glutamate receptor AMPA in rat brain synaptic membranes using [3H]-AMPA as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | = 9.7 uM | Binding affinity was determined against ionotropic glutamate receptor AMPA in rat brain synaptic membranes using [3H]-AMPA as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | > 10 uM | Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]-Glycine as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | > 10 uM | Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]-Glycine as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | = 16.5 uM | Inhibition of Ionotropic glutamate receptor AMPA induced depolarization in rat cortical wedge by application of 10 uM of AMPA | ChEMBL. | 7562904 |
IC50 (functional) | = 16.5 uM | Concentration of compound that inhibits by 50% depolarizations induced by 10 uM AMPA | ChEMBL. | 7562904 |
IC50 (binding) | = 16.5 uM | Inhibition of Ionotropic glutamate receptor AMPA induced depolarization in rat cortical wedge by application of 10 uM of AMPA | ChEMBL. | 7562904 |
IC50 (functional) | > 30 uM | Antagonistic activity against Ionotropic glutamate receptor AMPA induced LDH release in cultured rat cortical neurons after 24 hr 100 uM AMPA | ChEMBL. | 7562904 |
IC50 (functional) | > 30 uM | Antagonistic activity against Ionotropic glutamate receptor kainate induced LDH release in cultured cortical neurons in rat after 24 hr application of 500 uM of kainate | ChEMBL. | 7562904 |
IC50 (functional) | > 30 uM | Concentration of compound that inhibits by 50% LDH released by 24 hr application of 100 uM AMPA | ChEMBL. | 7562904 |
IC50 (functional) | > 30 uM | Concentration of compound that inhibits by 50% LDH released by 24 hr application of 500 uM kainate | ChEMBL. | 7562904 |
IC50 (functional) | > 30 uM | Antagonistic activity against Ionotropic glutamate receptor AMPA induced LDH release in cultured rat cortical neurons after 24 hr 100 uM AMPA | ChEMBL. | 7562904 |
IC50 (functional) | > 30 uM | Antagonistic activity against Ionotropic glutamate receptor kainate induced LDH release in cultured cortical neurons in rat after 24 hr application of 500 uM of kainate | ChEMBL. | 7562904 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.