Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic, kainate | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.5778 | 0.5313 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0235 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0193 | 0.7561 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0182 | 0.6934 | 0.6934 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0117 | 0.3169 | 0.3169 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.1897 | 0.1897 |
Brugia malayi | hypoxia-induced factor 1 | 0.015 | 0.5049 | 0.4504 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.2037 | 0.2037 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0113 | 0.2941 | 0.2941 |
Echinococcus multilocularis | glutamate receptor 2 | 0.008 | 0.0993 | 0.0993 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.1897 | 0.1897 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.2037 | 0.2037 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0235 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0117 | 0.3169 | 0.3314 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.008 | 0.0993 | 0.0993 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.2037 | 0.2037 |
Brugia malayi | hypothetical protein | 0.0162 | 0.5778 | 0.5313 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0098 | 0.2037 | 0.2037 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0113 | 0.2941 | 0.2941 |
Schistosoma mansoni | lipoxygenase | 0.0082 | 0.1124 | 0.02 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.015 | 0.5049 | 0.4504 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.008 | 0.0993 | 0.0993 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0087 | 0.141 | 0.141 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0182 | 0.6934 | 0.6934 |
Echinococcus granulosus | glutamate receptor 2 | 0.0098 | 0.2037 | 0.2037 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0117 | 0.3169 | 0.3169 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.2037 | 0.2037 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.2037 | 0.2037 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0098 | 0.2037 | 0.2037 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.2037 | 0.2037 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0098 | 0.2037 | 0.2037 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.43 uM | Binding affinity for the ionotropic glutamate receptor kainate in rat brain synaptic membranes using [3H]-kainate as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | = 0.43 uM | Binding affinity for the ionotropic glutamate receptor kainate in rat brain synaptic membranes using [3H]-kainate as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | = 2.5 uM | Binding affinity was determined against ionotropic glutamate receptor AMPA in rat brain synaptic membranes using [3H]-AMPA as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | = 2.5 uM | Binding affinity was determined against ionotropic glutamate receptor AMPA in rat brain synaptic membranes using [3H]-AMPA as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | > 10 uM | Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]-Glycine as radioligand | ChEMBL. | 7562904 |
IC50 (binding) | > 10 uM | Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]-Glycine as radioligand | ChEMBL. | 7562904 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.