Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0081 | 1 | 1 |
Schistosoma mansoni | jun-related protein | 0.0066 | 0.774 | 1 |
Echinococcus granulosus | Ankyrin | 0.0014 | 0.0018 | 0.0018 |
Echinococcus multilocularis | Ankyrin | 0.0014 | 0.0018 | 0.0018 |
Brugia malayi | hypothetical protein | 0.0064 | 0.7409 | 0.7409 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0081 | 1 | 1 |
Echinococcus multilocularis | jun protein | 0.0081 | 1 | 1 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0071 | 0.8515 | 0.8515 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0071 | 0.8515 | 0.8515 |
Echinococcus granulosus | jun protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.9669 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.774 | 1 |
Onchocerca volvulus | 0.0064 | 0.7409 | 0.5 | |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0014 | 0.0018 | 0.0023 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC25 (functional) | = 1.9 uM | Antiischemic potency by measurement of increase in time to contracture in globally ischemic isolated perfused rat hearts | ChEMBL. | 10479302 |
IC50 (functional) | = 3.3 uM | In vitro relaxation of rat aorta precontracted with methoxamine. | ChEMBL. | 10479302 |
Ratio (functional) | = 0.6 | Ratio of Antiischemic potency to vasorelaxant potency. | ChEMBL. | 10479302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.