Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, nicotinic, alpha 3 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, nicotinic, alpha 4 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cation transporter family protein | cholinergic receptor, nicotinic, alpha 3 (neuronal) | 505 aa | 486 aa | 34.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.003 | 0 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0201 | 0.6587 | 1 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0201 | 0.6587 | 1 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0 | 0.5 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0201 | 0.6587 | 0.6587 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.003 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0201 | 0.6587 | 1 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.029 | 1 | 1 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0201 | 0.6587 | 0.6587 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0201 | 0.6587 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0201 | 0.6587 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.003 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.6587 | 0.6587 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0201 | 0.6587 | 1 |
Onchocerca volvulus | Putative nachr subunit | 0.0201 | 0.6587 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5.26 | Antagonist activity at human nAChR alpha4/beta2 receptor expressed in HEK ts201 cells assessed as calcium accumulation by fluorescence analysis | ChEMBL. | 22285942 |
IC50 (functional) | = 5.37 | Antagonist activity at human nAChR alpha3/beta4 receptor expressed in HEK ts201 cells assessed as calcium accumulation by fluorescence analysis | ChEMBL. | 22285942 |
IC50 (functional) | = 8.4 uM | Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretion | ChEMBL. | 15203153 |
IC50 (functional) | = 8.4 uM | Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretion | ChEMBL. | 15203153 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.