Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily A, member 1 | References | |
Rattus norvegicus | Transient receptor potential cation channel subfamily A member 1 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transient receptor potential channel | 0.0004 | 0.00000010479 | 0.00000010595 |
Onchocerca volvulus | 0.0004 | 0 | 0.5 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0004 | 0 | 0.5 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0004 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0004 | 0 | 0.5 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0004 | 0 | 0.5 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0004 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | ankyrin repeat protein | 0.0384 | 0.9891 | 0.9898 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0384 | 0.9891 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.00000010479 | 0.0001 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.00000010479 | 0.0001 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0.00000010479 | 0.00000010479 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0384 | 0.9891 | 0.9891 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0004 | 0 | 0.5 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0004 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0004 | 0 | 0.5 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0004 | 0 | 0.5 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0004 | 0.0008 | 0.0008 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0008 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0004 | 0.0008 | 0.0008 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0.0008 | 0.0008 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0004 | 0 | 0.5 |
Leishmania major | hypothetical protein, unknown function | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0388 | 0.9992 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0004 | 0.00000010479 | 0.00000010487 |
Schistosoma mansoni | transient receptor potential channel | 0.0004 | 0.00000010479 | 0.00000010595 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.0004 | 0 | 0.5 |
Brugia malayi | olfactory channel protein osm-9 | 0.0004 | 0.0008 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0004 | 0.0008 | 0.0008 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0004 | 0.0008 | 0.0008 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0004 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.025 uM | Antagonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of AITC-induced Ca2+ influx preincubated for 2 mins followed by AITC addition measured for 2 mins by Fluo-4 dye based FLIPR assay | ChEMBL. | 26942860 |
IC50 (binding) | = 0.052 uM | Antagonist activity at human TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of AITC-induced Ca2+ influx preincubated for 2 mins followed by AITC addition measured for 2 mins by Fluo-4 dye based FLIPR assay | ChEMBL. | 26942860 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.