Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 2 | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.001 | 0.5 | 0.5 |
Onchocerca volvulus | 0.001 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.001 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.001 | 0.5 | 0.5 |
Onchocerca volvulus | 0.001 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.001 | 0.5 | 0.5 |
Onchocerca volvulus | 0.001 | 0.5 | 0.5 | |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.001 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.001 | 0.5 | 0.5 |
Onchocerca volvulus | 0.001 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.001 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.001 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.001 | 0.5 | 0.5 |
Onchocerca volvulus | 0.001 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.001 | 0.5 | 0.5 |
Onchocerca volvulus | 0.001 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.001 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.001 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.001 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.001 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 387 nM | Biochemical HTRF Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.