Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | References | |
Homo sapiens | transient receptor potential cation channel, subfamily V, member 4 | References | |
Rattus norvegicus | Transient receptor potential cation channel subfamily V member 4 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transient receptor potential channel | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0014 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.1 nM | Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of hypotonic solution-induced calcium mobilization by FLIPR assay | LITERATURE. | 27637151 |
IC50 (binding) | = 19 nM | Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FLIPR assay | LITERATURE. | 27637151 |
IC50 (binding) | = 19 nM | Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activation | LITERATURE. | 27634196 |
IC50 (binding) | = 800 nM | Antagonist activity at rat recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 300 nM 4alphaPDD-induced calcium mobilization by FLIPR assay | LITERATURE. | 27637151 |
IC50 (binding) | = 800 nM | Antagonist activity at rat TRPV4 assessed as inhibition of 4alpha-PDD-induced activation | LITERATURE. | 27634196 |
IC50 (binding) | > 10000 nM | Antagonist activity at human TRPV1 expressed in CHO cells assessed as blockade of 100 nM capsaicin-induced calcium mobilization by FLIPR assay | LITERATURE. | 27637151 |
INH (ADMET) | > 20 uM | Inhibition of CYP2C9 (unknown origin) | LITERATURE. | 27637151 |
INH (ADMET) | > 20 uM | Inhibition of CYP2C19 (unknown origin) | LITERATURE. | 27637151 |
INH (ADMET) | > 20 uM | Inhibition of CYP3A4 (unknown origin) | LITERATURE. | 27637151 |
INH (ADMET) | > 20 uM | Inhibition of CYP2D6 (unknown origin) | LITERATURE. | 27637151 |
INH (ADMET) | > 20 uM | Inhibition of CYP1A2 (unknown origin) | LITERATURE. | 27637151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.