Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0581 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0581 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0581 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta Tm (binding) | = 8 degrees C | DNA binding property using 100(microM) of calf thymus DNA (CTDNA) and at 100(microM) was determined | ChEMBL. | 12930141 |
Lambda-em (binding) | = 418 nm | DNA binding property using 100(microM) of calf thymus DNA (CTDNA) and at 100(microM) was determined | ChEMBL. | 12930141 |
Lambda-em (binding) | = 441 nm | DNA binding property using 100(microM) of calf thymus DNA (CTDNA) and at 100(microM) was determined | ChEMBL. | 12930141 |
Lambda-em (binding) | = 500 nm | DNA binding property using 100(microM) of calf thymus DNA (CTDNA) and at 10(microM) was determined | ChEMBL. | 12930141 |
Lambda-ex (binding) | = 350 nm | DNA binding property using 100(microM) of calf thymus DNA (CTDNA) and at 10(microM) was determined | ChEMBL. | 12930141 |
Lambda-ex (binding) | = 356 nm | DNA binding property using 100(microM) of calf thymus DNA (CTDNA) and at 100(microM) was determined | ChEMBL. | 12930141 |
Lambda-ex (binding) | = 391 nm | DNA binding property using 100(microM) of calf thymus DNA (CTDNA) and at 100(microM) was determined | ChEMBL. | 12930141 |
NA (functional) | 0 | In Vitro Cytotoxicity against BMG-1 (Human glioma cell line with a DNA index of 0.96; wild type TP 53) using MTT assay at 100 uM at 72 hours; No effect on the proliferation kinetics of BMG-1 cells. | ChEMBL. | 12930141 |
Protection (functional) | = 37 % | In Vitro Cytotoxicity against BMG-1 (Human brain malignant glioma cell line with a DNA index of 0.96; wild type TP 53) using Macrocolony assay at 10 uM at 72 hours | ChEMBL. | 12930141 |
Protection (functional) | = 100 % | In Vitro Cytotoxicity against BMG-1 (Human glioma cell line with a DNA index of 0.96; wild type TP 53) using Irradiation procedures followed by Macrocolony assay at 5Gy and 10 (microM) at 24 hr | ChEMBL. | 12930141 |
Survival (functional) | = 24 % | In Vitro Cytotoxicity against BMG-1 (Human glioma cell line with a DNA index of 0.96; wild type TP 53) using Irradiation procedures followed by Macrocolony assay at 2 Gy and 10 (microM) | ChEMBL. | 12930141 |
Survival (functional) | = 37 % | In Vitro Cytotoxicity against BMG-1 (Human glioma cell line with a DNA index of 0.96; wild type TP 53) using Irradiation procedures followed by Macrocolony assay at 5Gy and 10 (microM) | ChEMBL. | 12930141 |
Survival (functional) | = 92 % | In Vitro Cytotoxicity against BMG-1 (Human brain malignant glioma cell line with a DNA index of 0.96; wild type TP 53) using Macrocolony assay (clonogenicity) at 100 uM at 72 hours | ChEMBL. | 12930141 |
Survival (functional) | = 100 % | In Vitro Cytotoxicity against BMG-1 (Human glioma cell line with a DNA index of 0.96; wild type TP 53) using Irradiation procedures followed by Macrocolony assay at 10 Gy and 10 (microM) | ChEMBL. | 12930141 |
Tm (binding) | = 78 degrees C | DNA binding property using 100(microM) of calf thymus DNA (CTDNA) and at 100(microM) was determined | ChEMBL. | 12930141 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.