Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, AMPA 2 | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | glutamate receptor, ionotropic, AMPA 2 | 883 aa | 810 aa | 34.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glutamate receptor 1 precursor | 0.013 | 0.3788 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.0161 | 0.0296 |
Echinococcus granulosus | glutamate receptor 2 | 0.0116 | 0.2297 | 0.4229 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0145 | 0.5357 | 0.9864 |
Echinococcus granulosus | nmda type glutamate receptor | 0.011 | 0.173 | 0.3185 |
Echinococcus multilocularis | glutamate receptor 2 | 0.013 | 0.3788 | 0.6975 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0145 | 0.5357 | 0.9864 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0124 | 0.3221 | 0.5931 |
Echinococcus granulosus | glutamate receptor 2 | 0.0145 | 0.5357 | 0.9864 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0124 | 0.3221 | 0.5931 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0145 | 0.5431 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0145 | 0.5357 | 0.9864 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0145 | 0.5431 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.013 | 0.3788 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.0161 | 0.0296 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.013 | 0.3788 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0116 | 0.2297 | 0.4229 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.011 | 0.173 | 0.3185 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (binding) | = 23 % | Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells at 125 uM measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate | ChEMBL. | 26919761 |
%max (binding) | = 38 % | Positive allosteric modulation of human GluA2 AMPAR flip isomer expressed in Dox-inducible cells at 125 uM measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate | ChEMBL. | 26919761 |
%max (binding) | = 160 % | Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells at 125 uM measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate/glycine | ChEMBL. | 26919761 |
EC50 (binding) | = 0.9 uM | Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate/glycine | ChEMBL. | 26919761 |
EC50 (binding) | = 1.1 uM | Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate | ChEMBL. | 26919761 |
EC50 (binding) | = 32.6 uM | Positive allosteric modulation of human GluA2 AMPAR flip isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate | ChEMBL. | 26919761 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.