Detailed information for compound 2156599

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 472.222 | Formula: C26H28N6O3
  • H donors: 5 H acceptors: 5 LogP: 3.12 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 0
  • SMILES: ONC(=O)CCCCC(=O)Nc1ccc(cc1)c1cc2c([nH]1)ncnc2N[C@@H](c1ccccc1)C
  • InChi: InChI=1S/C26H28N6O3/c1-17(18-7-3-2-4-8-18)29-25-21-15-22(31-26(21)28-16-27-25)19-11-13-20(14-12-19)30-23(33)9-5-6-10-24(34)32-35/h2-4,7-8,11-17,35H,5-6,9-10H2,1H3,(H,30,33)(H,32,34)(H2,27,28,29,31)/t17-/m1/s1
  • InChiKey: BNNHALXHKHKDOT-QGZVFWFLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 1 No references
Homo sapiens histone deacetylase 10 No references
Homo sapiens histone deacetylase 3 No references
Homo sapiens histone deacetylase 6 No references
Homo sapiens histone deacetylase 2 No references
Homo sapiens epidermal growth factor receptor No references
Homo sapiens kinase insert domain receptor No references
Homo sapiens histone deacetylase 8 No references
Homo sapiens histone deacetylase 7 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei histone deacetylase 2 histone deacetylase 2 488 aa 427 aa 29.0 %
Plasmodium falciparum histone deacetylase 1 histone deacetylase 8 286 aa 241 aa 44.8 %
Trypanosoma cruzi histone deacetylase, putative histone deacetylase 3 428 aa 374 aa 30.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/EGFR protein kinase 0.0181 0.5613 0.5613
Trichomonas vaginalis histone deacetylase, putative 0.0311 1 0.5
Echinococcus granulosus histone deacetylase 6 0.0282 0.9028 0.9028
Plasmodium falciparum histone deacetylase 1 0.0311 1 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0311 1 1
Echinococcus granulosus histone deacetylase 0.0282 0.9028 0.9028
Plasmodium vivax histone deacetylase 2, putative 0.0282 0.9028 0.8254
Schistosoma mansoni tyrosine kinase 0.0096 0.273 0.273
Echinococcus multilocularis epidermal growth factor receptor 0.0098 0.2799 0.2729
Schistosoma mansoni histone deacetylase hda2 0.0146 0.4434 0.4434
Schistosoma mansoni histone deacetylase 0.0311 1 1
Schistosoma mansoni tyrosine kinase 0.0098 0.2799 0.2799
Schistosoma mansoni histone deacetylase 4 5 0.0282 0.9028 0.9028
Trypanosoma cruzi histone deacetylase, putative 0.0282 0.9028 0.8254
Schistosoma mansoni tyrosine kinase 0.0098 0.2799 0.2799
Onchocerca volvulus 0.0167 0.5125 0.8065
Schistosoma mansoni tyrosine kinase 0.0096 0.273 0.273
Plasmodium vivax histone deacetylase 1, putative 0.0311 1 1
Echinococcus granulosus histone deacetylase 1 0.0311 1 1
Trypanosoma brucei histone deacetylase 3 0.0282 0.9028 0.8254
Loa Loa (eye worm) hypothetical protein 0.0146 0.4434 0.4434
Schistosoma mansoni histone deacetylase 4 5 0.0282 0.9028 0.9028
Brugia malayi Furin-like cysteine rich region family protein 0.0181 0.5613 0.4854
Plasmodium vivax histone deacetylase, putative 0.0282 0.9028 0.8254
Echinococcus multilocularis histone deacetylase 6 0.029 0.928 0.9273
Trypanosoma brucei histone deacetylase 1 0.0311 1 1
Entamoeba histolytica histone deacetylase, putative 0.0311 1 0.5
Echinococcus multilocularis histone deacetylase 1 0.0311 1 1
Trichomonas vaginalis histone deacetylase, putative 0.0311 1 0.5
Schistosoma mansoni histone deacetylase 0.0311 1 1
Trypanosoma cruzi histone deacetylase, putative 0.0282 0.9028 0.8254
Echinococcus multilocularis epidermal growth factor receptor 0.0181 0.5613 0.557
Echinococcus multilocularis histone deacetylase 0.0282 0.9028 0.9019
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0311 1 0.5
Schistosoma mansoni tyrosine kinase 0.0059 0.1475 0.1475
Trypanosoma brucei histone deacetylase, putative 0.0282 0.9028 0.8254
Echinococcus multilocularis histone deacetylase 6 0.0282 0.9028 0.9019
Trichomonas vaginalis histone deacetylase, putative 0.0311 1 0.5
Loa Loa (eye worm) histone deacetylase 7A 0.0282 0.9028 0.9028
Brugia malayi histone deacetylase 11 0.0146 0.4434 0.3471
Leishmania major histone deacetylase, putative 0.0311 1 1
Echinococcus granulosus insulin receptor 0.0059 0.1475 0.1475
Loa Loa (eye worm) histone deacetylase 1 0.0311 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0184 0.5697 0.4953
Echinococcus granulosus roundabout 2 0.0018 0.0097 0.0097
Loa Loa (eye worm) TK/INSR protein kinase 0.0059 0.1475 0.1475
Echinococcus granulosus histone deacetylase 6 0.029 0.928 0.928
Loa Loa (eye worm) hypothetical protein 0.0144 0.4343 0.4343
Leishmania major histone deacetylase, putative 0.0311 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0097 0.0097
Echinococcus granulosus histone deacetylase 8 0.0146 0.4434 0.4434
Trichomonas vaginalis histone deacetylase, putative 0.0311 1 0.5
Loa Loa (eye worm) histone deacetylase 11 0.0146 0.4434 0.4434
Brugia malayi Histone deacetylase family protein 0.0282 0.9028 0.886
Trichomonas vaginalis histone deacetylase, putative 0.0311 1 0.5
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0184 0.5697 0.5697
Loa Loa (eye worm) hypothetical protein 0.0018 0.0097 0.0097
Schistosoma mansoni tyrosine kinase 0.0096 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.0311 1 1
Echinococcus multilocularis histone deacetylase 3 0.0311 1 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0098 0.2799 0.2799
Giardia lamblia Histone deacetylase 0.0311 1 0.5
Echinococcus multilocularis insulin receptor 0.0059 0.1475 0.1391
Trypanosoma cruzi histone deacetylase 1, putative 0.0311 1 1
Echinococcus granulosus histone deacetylase 7 0.0282 0.9028 0.9028
Loa Loa (eye worm) histone deacetylase 0.0282 0.9028 0.9028
Echinococcus granulosus epidermal growth factor receptor 0.0181 0.5613 0.5613
Echinococcus granulosus epidermal growth factor receptor 0.0098 0.2799 0.2799
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0311 1 0.5
Echinococcus multilocularis 0.0056 0.1379 0.1295
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0311 1 0.5
Onchocerca volvulus Tyrosine kinase homolog 0.0172 0.5291 1
Schistosoma mansoni histone deacetylase 1 2 3 0.0146 0.4434 0.4434
Brugia malayi histone deacetylase 1 (HD1) 0.0311 1 1
Echinococcus granulosus histone deacetylase 3 0.0311 1 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.4091 0.4091
Loa Loa (eye worm) histone deacetylase 3 0.0311 1 1
Schistosoma mansoni histone deacetylase hda2 0.029 0.928 0.928
Toxoplasma gondii histone deacetylase HDAC3 0.0311 1 1
Schistosoma mansoni tyrosine kinase 0.0181 0.5613 0.5613
Toxoplasma gondii histone deacetylase HDAC1 0.0282 0.9028 0.8254
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0059 0.1475 0.1391
Schistosoma mansoni tyrosine kinase 0.0059 0.1475 0.1475
Echinococcus multilocularis histone deacetylase 6 0.0282 0.9028 0.9019
Trypanosoma brucei histone deacetylase 4 0.0282 0.9028 0.8254
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0059 0.1475 0.1475
Trypanosoma cruzi histone deacetylase, putative 0.0282 0.9028 0.8254
Brugia malayi Histone deacetylase 1 0.0311 1 1
Echinococcus granulosus histone deacetylase 6 0.0282 0.9028 0.9028
Echinococcus multilocularis histone deacetylase 7 0.0282 0.9028 0.9019
Echinococcus multilocularis histone deacetylase 8 0.0146 0.4434 0.4379
Trichomonas vaginalis histone deacetylase, putative 0.0311 1 0.5
Brugia malayi Histone deacetylase family protein 0.0282 0.9028 0.886
Toxoplasma gondii histone deacetylase HDAC2 0.0311 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) <= 0.1 uM Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate after 1 hr by fluorimetric method PATENT. No reference
IC50 (binding) <= 0.1 uM Inhibition of N-terminal GST-fused human EGFR (His672 to Ala1210 residues) expressed in baculovirus expression system using biotinylated PTP1B at Tyr66 as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by DELFIA PATENT. No reference
IC50 (binding) = 0.1 uM Inhibition of N-terminal GST-His6-thrombin cleavage site-fused human VEGFR2 (Asp805 to Val1356 residues) expressed in baculovirus expression system using biotinylated gastrin precursor at Tyr87 as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by DELFIA method PATENT. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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