Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.8533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.5828 | 0.683 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0102 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0348 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0102 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0102 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0102 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0102 | 0 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0102 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0102 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0102 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0102 | 0 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0102 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0282 | 0.7295 | 0.8549 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0102 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0102 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0102 | 0 | 0.5 |
Onchocerca volvulus | 0.0348 | 1 | 1 | |
Entamoeba histolytica | aminopeptidase, putative | 0.0102 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0348 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 184 uM | Concentration required to reduce the viability of mock-infected MT-4 cells | ChEMBL. | 7830280 |
CC50 (functional) | = 192 uM | Cellular cytotoxicity against HUT-78 cells. | ChEMBL. | 7562918 |
CC50 (functional) | = 192 uM | Cellular cytotoxicity against HUT-78 cells. | ChEMBL. | 7562918 |
EC50 (functional) | = 0.0408 uM | Concentration required to protect the virus infected cells against viral cytopathicity was measured on HIV-1(IIIB) virus strain in MT-4 cells | ChEMBL. | 7830280 |
EC50 (functional) | = 0.0618 uM | Concentration required to protect the virus infected cells against viral cytopathicity was measured on HIV-2(ROD) virus strain in MT-4 cells | ChEMBL. | 7830280 |
Log 1/EC50 (functional) | = 1.21 | Antiretroviral activity against HIV-2 infected HUT-78 cells. | ChEMBL. | 7562918 |
Log 1/EC50 (functional) | = 1.39 | Antiretroviral activity against HIV-1 infected HUT-78 cells. | ChEMBL. | 7562918 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.