Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.012 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.012 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.012 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.012 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.012 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.012 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.012 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.012 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.012 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.012 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.012 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.012 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.012 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.012 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.012 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.012 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.012 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.012 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.012 | 0.5 | 0.5 |
Onchocerca volvulus | 0.012 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.012 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.012 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.012 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.012 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.012 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.012 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.012 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -2 % | Percent inhibition in elastase-induced lung haemorrhage, when the compound is dosed orally at 30 mg/kg 30 min before challenge by HLE (Human leukocyte elastase) | ChEMBL. | 1433189 |
Inhibition (functional) | = -2 % | Percent inhibition in elastase-induced lung haemorrhage, when the compound is dosed orally at 30 mg/kg 30 min before challenge by HLE (Human leukocyte elastase) | ChEMBL. | 1433189 |
k obs / 1 (binding) | = 1500 M-1 s-1 | elastase inhibitory activity, evaluated for second order rate constant (time-dependent inhibition) | ChEMBL. | 1433189 |
k obs / 1 (binding) | = 1500 M-1 s-1 | elastase inhibitory activity, evaluated for second order rate constant (time-dependent inhibition) | ChEMBL. | 1433189 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.