Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.9586 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0245 | 0.2444 | 0.2444 |
Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.0166 | 0 | 0.5 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0374 | 0.6414 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0277 | 0.3426 | 0.5342 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0374 | 0.6414 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0491 | 1 | 1 |
Leishmania major | farnesyltransferase beta subunit | 0.0166 | 0 | 0.5 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0268 | 0.3158 | 0.3158 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0268 | 0.3158 | 0.4405 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0374 | 0.6414 | 1 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0374 | 0.6414 | 0.8946 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0245 | 0.2444 | 0.2549 |
Toxoplasma gondii | hypothetical protein | 0.0277 | 0.3426 | 1 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0166 | 0 | 0.5 |
Echinococcus multilocularis | jun protein | 0.0491 | 1 | 1 |
Schistosoma mansoni | jun-related protein | 0.0399 | 0.7169 | 1 |
Echinococcus granulosus | jun protein | 0.0491 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0491 | 1 | 1 |
Onchocerca volvulus | 0.0385 | 0.6755 | 0.5 | |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0374 | 0.6414 | 1 |
Brugia malayi | hypothetical protein | 0.0385 | 0.6755 | 0.6755 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0374 | 0.6414 | 1 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0268 | 0.3158 | 0.3158 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.6414 | 0.6691 |
Schistosoma mansoni | hypothetical protein | 0.0399 | 0.7169 | 1 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0268 | 0.3158 | 0.3295 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0268 | 0.3158 | 0.3158 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0374 | 0.6414 | 0.6691 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0268 | 0.3158 | 0.4924 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0374 | 0.6414 | 0.6414 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0374 | 0.6414 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.3078 | 0.3211 |
Brugia malayi | hypothetical protein | 0.0266 | 0.3078 | 0.3078 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0166 | 0 | 0.5 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0374 | 0.6414 | 0.6414 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.0268 | 0.3158 | 0.4924 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0374 | 0.6414 | 1 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0268 | 0.3158 | 0.4405 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0374 | 0.6414 | 0.6414 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 22 % | Ability of the compound to inhibit phenylquinone induced writhing, in rat at dose 25 mg/Kg administered per orally | ChEMBL. | 6607999 |
Inhibition (functional) | = 35 % | Ability of the compound to inhibit Carrageenan-induced paw edema in rat at dose 20 mg/Kg administered per orally | ChEMBL. | 6607999 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.