Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0185 | 0.2147 | 0.5 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0231 | 0.3148 | 0.4054 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0231 | 0.3148 | 0.133 |
Brugia malayi | hypothetical protein | 0.0426 | 0.7439 | 0.7439 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0231 | 0.3148 | 0.1275 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0185 | 0.2147 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.4536 | 0.3175 |
Brugia malayi | hypoxia-induced factor 1 | 0.0271 | 0.4036 | 0.4036 |
Toxoplasma gondii | hypothetical protein | 0.0137 | 0.1091 | 0.5 |
Echinococcus granulosus | jun protein | 0.0542 | 1 | 1 |
Schistosoma mansoni | jun-related protein | 0.0441 | 0.7766 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0542 | 1 | 1 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0231 | 0.3148 | 0.3148 |
Onchocerca volvulus | 0.0426 | 0.7439 | 0.5 | |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0185 | 0.2147 | 0.5134 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0185 | 0.2147 | 0.2765 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0231 | 0.3148 | 0.4054 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0185 | 0.2147 | 0.5134 |
Echinococcus multilocularis | jun protein | 0.0542 | 1 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0271 | 0.4036 | 0.2509 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0542 | 1 | 1 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0231 | 0.3148 | 1 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0185 | 0.2147 | 0.2147 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0231 | 0.3148 | 0.1275 |
Brugia malayi | hypothetical protein | 0.0294 | 0.4536 | 0.4536 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0185 | 0.2147 | 0.5134 |
Schistosoma mansoni | hypothetical protein | 0.0441 | 0.7766 | 1 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0185 | 0.2147 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0528 | 0.9673 | 1 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.0231 | 0.3148 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 48 uM | Inhibitory activity against recombinant Mycobacterium tuberculosis beta-ketoacyl-Acyl Carrier Protein synthase mtFabH condensing enzyme | ChEMBL. | 14698162 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.