Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase | No references | |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 8 | No references | |
Homo sapiens | baculoviral IAP repeat containing 2 | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Loa Loa (eye worm) | cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | cytochrome P450, family 2, subfamily C, polypeptide 8 | 490 aa | 435 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1148 | 0.1148 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0114 | 1 | 1 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0114 | 1 | 1 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0114 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0037 | 0.1148 | 0.1148 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0114 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 1 | 1 | |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0114 | 1 | 1 |
Onchocerca volvulus | Deterin homolog | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1148 | 0.1148 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0114 | 1 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0037 | 0.1148 | 0.1148 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 nM | Binding Assays (DELFIA) | BINDINGDB. | No reference |
IC50 (binding) | = 207 nM | Binding Assays (DELFIA) | BINDINGDB. | No reference |
IC50 (binding) | = 11000 nM | Inhibition Assays | BINDINGDB. | No reference |
IC50 (binding) | = 35000 nM | Inhibition Assays | BINDINGDB. | No reference |
IC50 (binding) | = 38000 nM | Inhibition Assays | BINDINGDB. | No reference |
IC50 (binding) | > 50000 nM | Inhibition Assays | BINDINGDB. | No reference |
IC50 (binding) | > 50000 nM | Inhibition Assays | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.