Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | legumain | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | peptidase C13 family protein | 0.0183 | 1 | 0.5 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0183 | 1 | 0.5 |
Schistosoma mansoni | family C13 non-peptidase homologue (C13 family) | 0.0183 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0183 | 1 | 0.5 |
Schistosoma mansoni | hemoglobinase (C13 family) | 0.0183 | 1 | 1 |
Onchocerca volvulus | Legumain homolog | 0.0183 | 1 | 0.5 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0183 | 1 | 0.5 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0183 | 1 | 0.5 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0183 | 1 | 0.5 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0183 | 1 | 0.5 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0183 | 1 | 0.5 |
Schistosoma mansoni | hemoglobinase (C13 family) | 0.0183 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.071 uM | Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-MCA substrate measured every 2 mins for 60 mins by microplate reader analysis | ChEMBL. | 26522952 |
IC50 (binding) | > 50 uM | Inhibition of recombinant caspase 8 (unknown origin) using IETD-AFC fluorogenic substrate | ChEMBL. | 26522952 |
IC50 (binding) | > 50 uM | Inhibition of recombinant cathepsin B (unknown origin) using Z-Leu-Arg-AMC fluorogenic substrate | ChEMBL. | 26522952 |
IC50 (binding) | > 50 uM | Inhibition of USP17 in human HEK293T cells using fluorogenic substrate ub-rhodamine110 preincubated for 30 mins followed by substrate addition measured every 4 mins for 1 hr by microplate reader analysis | ChEMBL. | 26522952 |
IC50 (binding) | > 50 uM | Inhibition of recombinant caspase 3 (unknown origin) using DEVD-AFC fluorogenic substrate | ChEMBL. | 26522952 |
Inhibition (binding) | Inhibition of legumain in human MCF7 cells using Z-Ala-Ala-Asn-MCA substrate at 30 uM incubated for 48 hrs by microplate reader analysis | ChEMBL. | 26522952 | |
Inhibition (binding) | = 90 % | Inhibition of legumain in human MCF7 cells using Z-Ala-Ala-Asn-MCA substrate at 30 uM incubated for 24 hrs by microplate reader analysis | ChEMBL. | 26522952 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.