Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.0003 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0003 | 0 | 0.5 |
Plasmodium falciparum | protein kinase, putative | 0.0003 | 0 | 0.5 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0249 | 1 | 1 |
Echinococcus granulosus | activin receptor type | 0.0003 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0003 | 0 | 0.5 |
Echinococcus granulosus | dual specificity testis-specific protein kinase | 0.0003 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | NEK/NEK6 protein kinase | 0.0249 | 1 | 0.5 |
Leishmania major | protein kinase, putative | 0.0003 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | activin receptor type | 0.0003 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity testis specific protein kinase | 0.0003 | 0 | 0.5 |
Chlamydia trachomatis | serine/threonine protein kinase | 0.0249 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Toxicity in C57BL/6 mouse assessed as histopathology at 10 or 20 mg/kg, iv administered as single dose | ChEMBL. | 26632965 | |
Activity (ADMET) | Toxicity in C57BL/6 mouse assessed as hematology at 10 or 20 mg/kg, iv administered as single dose | ChEMBL. | 26632965 | |
Activity (ADMET) | Toxicity in C57BL/6 mouse assessed as gross pathology at 10 or 20 mg/kg, iv administered as single dose | ChEMBL. | 26632965 | |
Activity (ADMET) | Toxicity in C57BL/6 mouse assessed as clinical chemistries following animal sacrifice at 10 or 20 mg/kg, iv administered as single dose | ChEMBL. | 26632965 | |
Cmax (ADMET) | = 5.8 uM | Cmax in C57BL/6 mouse at 20 mg/kg, iv by UPLC-MS analysis | ChEMBL. | 26632965 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.