Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin E receptor 2 (subtype EP2), 53kDa | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 4 (subtype EP4) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 1 (subtype EP1), 42kDa | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 3 (subtype EP3) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0185 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0185 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0185 | 0 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0185 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0185 | 0 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0486 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0486 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0486 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0486 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0486 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0486 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0486 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0486 | 1 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0185 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0185 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.15 uM | Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line. | ChEMBL. | 14552786 |
Ki (binding) | = 0.15 uM | Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line. | ChEMBL. | 14552786 |
Ki (binding) | = 0.23 uM | Affinity at human Prostanoid EP1 receptor in the human embryonic kidney (HEK) 293 cell line. | ChEMBL. | 14552786 |
Ki (binding) | = 0.23 uM | Affinity at human Prostanoid EP1 receptor in the human embryonic kidney (HEK) 293 cell line. | ChEMBL. | 14552786 |
Ki (binding) | = 0.44 uM | Affinity at human Prostanoid EP4 receptor in the human embryonic kidney (HEK) 293 cell line. | ChEMBL. | 14552786 |
Ki (binding) | = 0.44 uM | Affinity at human Prostanoid EP4 receptor in the human embryonic kidney (HEK) 293 cell line. | ChEMBL. | 14552786 |
Ki (binding) | = 2.3 uM | Affinity at human Prostanoid EP3 receptor in the human embryonic kidney (HEK) 293 cell line. | ChEMBL. | 14552786 |
Ki (binding) | = 2.3 uM | Affinity at human Prostanoid EP3 receptor in the human embryonic kidney (HEK) 293 cell line. | ChEMBL. | 14552786 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.