Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidase homolog | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.012 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.012 | 0.5 | 0.5 |
Onchocerca volvulus | 0.012 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.012 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Onchocerca volvulus | 0.012 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.012 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.012 | 0.5 | 0.5 |
Onchocerca volvulus | 0.012 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.012 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.012 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1203 uM | Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL | ChEMBL. | 14711309 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli W3110 | ChEMBL. | 17149863 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli W3110 | ChEMBL. | 17149863 |
Log IC50 (functional) | = 2.92 | pIC50 value for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL | ChEMBL. | 14711309 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.