Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 4 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
KB (functional) | = 215 nM | Functional activity on isolated guinea pig urinary bladder strips using carbachol agonist for Muscarinic acetylcholine receptors | ChEMBL. | 9371246 |
Kb (functional) | = 215 nM | Functional activity on isolated guinea pig urinary bladder strips using carbachol agonist for Muscarinic acetylcholine receptors | ChEMBL. | 9371246 |
Ki (binding) | = 140 nM | Ability of compound to displace (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in cerebral cortex from Guinea Pig. | ChEMBL. | 9371246 |
Ki (binding) | = 140 nM | Ability of compound to displace (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in cerebral cortex from Guinea Pig. | ChEMBL. | 9371246 |
Ki (binding) | = 210 nM | Ability of compound to displace (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the heart from Guinea Pig. | ChEMBL. | 9371246 |
Ki (binding) | = 210 nM | Ability of compound to displace (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the heart from Guinea Pig. | ChEMBL. | 9371246 |
Ki (binding) | = 390 nM | Affinity for Muscarinic acetylcholine receptors in urinary bladder from Guinea Pig by (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB displacement. | ChEMBL. | 9371246 |
Ki (binding) | = 390 nM | Affinity for Muscarinic acetylcholine receptors in urinary bladder from Guinea Pig by (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB displacement. | ChEMBL. | 9371246 |
Ki (binding) | = 420 nM | Ability of compound to displace (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the parotid gland from Guinea Pig. | ChEMBL. | 9371246 |
Ki (binding) | = 420 nM | Ability of compound to displace (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the parotid gland from Guinea Pig. | ChEMBL. | 9371246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.