Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0117 | 0.6154 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1165 | 0.1893 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0112 | 0.5759 | 0.5759 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1165 | 0.1893 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0117 | 0.6154 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1165 | 0.1893 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1165 | 0.1893 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 74 nM | Binding affinity for rat striatum Dopamine receptor D3 (sf9 cells) by [3H]-7-OH-DPAT displacement. | ChEMBL. | 12930145 |
Ki (binding) | = 244 nM | Binding affinity for rat striatum Dopamine receptor D2 by [3H]-spiperone displacement. | ChEMBL. | 12930145 |
Ki (binding) | = 2676 nM | Binding affinity for rat striatum dopamine Dopamine receptor D1 by [3H]-SCH- -2339 displacement. | ChEMBL. | 12930145 |
NT (binding) | 0 | Binding affinity for rat hippocampus 5-hydroxytryptamine 1A receptor by inhibition of [3H]-8-OH-DPAT binding; Not tested | ChEMBL. | 12930145 |
NT (binding) | 0 | Binding affinity for rat cortex alpha-1 adrenergic receptor was determined by inhibition of [3H]-prazosin binding; Not tested | ChEMBL. | 12930145 |
NT (binding) | 0 | Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding; Not tested | ChEMBL. | 12930145 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.