Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Monoamine oxidase B | Starlite/ChEMBL | References |
Rattus norvegicus | Monoamine oxidase A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | Monoamine oxidase B | 520 aa | 479 aa | 21.7 % |
Dictyostelium discoideum | hypothetical protein | Monoamine oxidase B | 520 aa | 538 aa | 21.0 % |
Dictyostelium discoideum | hypothetical protein | Monoamine oxidase B | 520 aa | 531 aa | 23.2 % |
Onchocerca volvulus | Mitochondrial fission process protein 1 homolog | Monoamine oxidase B | 520 aa | 469 aa | 22.0 % |
Dictyostelium discoideum | amine oxidase | Monoamine oxidase B | 520 aa | 489 aa | 29.0 % |
Dictyostelium discoideum | hypothetical protein | Monoamine oxidase B | 520 aa | 539 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0622 | 0.8117 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0442 | 0.4566 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0717 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0622 | 0.8117 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0232 | 0.043 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0667 | 0.9004 | 1 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0371 | 0.3178 | 0.6643 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0622 | 0.8117 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0442 | 0.4566 | 0.5071 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0232 | 0.043 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0371 | 0.3178 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0442 | 0.4566 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0232 | 0.043 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0371 | 0.3178 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0371 | 0.3178 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0622 | 0.8117 | 0.5 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.0371 | 0.3178 | 0.6959 |
Brugia malayi | thymidylate synthase | 0.0442 | 0.4566 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0442 | 0.4566 | 1 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0232 | 0.043 | 1 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0371 | 0.3178 | 0.6643 |
Loa Loa (eye worm) | thymidylate synthase | 0.0442 | 0.4566 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0622 | 0.8117 | 0.5 |
Onchocerca volvulus | 0.0442 | 0.4566 | 0.5 | |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0371 | 0.3178 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0622 | 0.8117 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0442 | 0.4566 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 2.98 | Calculated partition coefficient (clogP) | ChEMBL. | 9748356 |
IC50 (binding) | = -6.2 | Inhibitory activity against Monoamine oxidase B from rat brain mitchondria | ChEMBL. | 9748356 |
IC50 (binding) | > 0.5 uM | Ability to inhibit Monoamine oxidase B enzyme | ChEMBL. | 7562919 |
IC50 (binding) | > 0.5 uM | Ability to inhibit Monoamine oxidase B enzyme | ChEMBL. | 7562919 |
IC50 (binding) | = 1 uM | Ability to inhibit Monoamine oxidase A enzyme | ChEMBL. | 7562919 |
IC50 (binding) | = 1 uM | Ability to inhibit Monoamine oxidase A enzyme | ChEMBL. | 7562919 |
Log IC50 (binding) | = 6.2 | Inhibitory activity against Monoamine oxidase B from rat brain mitchondria | ChEMBL. | 9748356 |
logP (ADMET) | = 1.66 | Partition coefficient (logP) (cyclohexane) | ChEMBL. | 9748356 |
logP (ADMET) | > 3 | Partition coefficient (logP) | ChEMBL. | 9748356 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.