Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.0085 | 0.6821 | 0.6918 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0035 | 0.0881 | 0.0893 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0035 | 0.0881 | 0.0893 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0085 | 0.6821 | 0.6918 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0035 | 0.0881 | 0.0893 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0078 | 0.594 | 0.6025 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0035 | 0.0881 | 0.0893 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0035 | 0.0881 | 0.0893 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0078 | 0.594 | 0.6025 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0035 | 0.0881 | 0.0893 |
Echinococcus granulosus | glutamate receptor 2 | 0.0035 | 0.0881 | 0.0893 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0033 | 0.0739 | 0.075 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0035 | 0.0881 | 0.0893 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0035 | 0.0881 | 0.0893 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0111 | 0.9859 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0027 | 0 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0035 | 0.0881 | 0.0893 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0111 | 0.9859 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.7 nM | Ability of compound to displace (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in cerebral cortex from Guinea Pig. | ChEMBL. | 9371246 |
Ki (binding) | = 5.7 nM | Ability of compound to displace (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in cerebral cortex from Guinea Pig. | ChEMBL. | 9371246 |
Ki (binding) | = 10.7 nM | Ability of compound to displace (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the heart from Guinea Pig. | ChEMBL. | 9371246 |
Ki (binding) | = 10.7 nM | Ability of compound to displace (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the heart from Guinea Pig. | ChEMBL. | 9371246 |
Ki (binding) | = 25 nM | Ability of compound to displace (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the parotid gland from Guinea Pig. | ChEMBL. | 9371246 |
Ki (binding) | = 25 nM | Ability of compound to displace (-)-[3H]-3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the parotid gland from Guinea Pig. | ChEMBL. | 9371246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.