Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0.2747 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0199 | 1 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0199 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0067 | 0.2112 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2747 | 0.2747 |
Leishmania major | dihydroorotate dehydrogenase | 0.0199 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2747 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0199 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0199 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0199 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0199 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0.2747 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0.2747 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0199 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0199 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2747 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0199 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0067 | 0.2112 | 0.2112 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0.2747 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2747 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0199 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2747 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0.2747 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0.2747 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0199 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0199 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0078 | 0.2747 | 0.2747 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0199 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2747 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration for Proteus vulgaris (ATCC-6059) by agar dilution method | ChEMBL. | 7966140 |
MIC (functional) | = 1 ug ml-1 | In vitro minimum inhibitory concentration for Enterobacter cloacae (ATCC-27508) by agar dilution method | ChEMBL. | 7966140 |
MIC (functional) | = 2 ug ml-1 | In vitro minimum inhibitory concentration for Klebsiella pneumoniae (ATCC-10031) by agar dilution method | ChEMBL. | 7966140 |
MIC (functional) | = 4 ug ml-1 | In vitro minimum inhibitory concentration for Escherichia coli (ATCC-10536) by agar dilution method | ChEMBL. | 7966140 |
MIC (functional) | = 4 ug ml-1 | In vitro minimum inhibitory concentration for S. marcescens (ATCC-27117) by agar dilution method | ChEMBL. | 7966140 |
MIC (functional) | = 4 ug ml-1 | In vitro minimum inhibitory concentration for Escherichia coli (ATCC-10536) by agar dilution method | ChEMBL. | 7966140 |
MIC (functional) | = 8 ug ml-1 | In vitro minimum inhibitory concentration for Citrobacter freundii (ATCC-8090) by agar dilution method | ChEMBL. | 7966140 |
MIC (functional) | = 8 ug ml-1 | In vitro minimum inhibitory concentration for Salmonella typhimurium (ATCC-14028) by agar dilution method | ChEMBL. | 7966140 |
MIC (functional) | = 32 ug ml-1 | In vitro minimum inhibitory concentration for Enterobacter aerogenes (ATCC-29751) by agar dilution method | ChEMBL. | 7966140 |
MIC (functional) | = 32 ug ml-1 | In vitro minimum inhibitory concentration for Pseudomonas aeruginosa (ATCC-27853) by agar dilution method | ChEMBL. | 7966140 |
MIC (functional) | = 32 ug ml-1 | In vitro minimum inhibitory concentration for Pseudomonas aeruginosa (ATCC-10145) by agar dilution method | ChEMBL. | 7966140 |
MIC (functional) | > 128 ug ml-1 | In vitro minimum inhibitory concentration for Staphylococcus aureus (ATCC6538p) by agar dilution method | ChEMBL. | 7966140 |
MIC (functional) | > 128 ug ml-1 | In vitro minimum inhibitory concentration for Staphylococcus epidermidis (ATCC-12228) by agar dilution method | ChEMBL. | 7966140 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.