Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Androgen Receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0085 | 0.4311 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0167 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0977 | 0.2265 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0977 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0977 | 0.2265 |
Onchocerca volvulus | 0.0067 | 0.3059 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.4152 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0167 | 1 | 1 |
Schistosoma mansoni | jun-related protein | 0.0069 | 0.3218 | 1 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0022 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0977 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0977 | 0.3034 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0977 | 0.3034 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0167 | 1 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0167 | 1 | 1 |
Echinococcus granulosus | jun protein | 0.0085 | 0.4311 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0977 | 0.5 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0167 | 1 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0085 | 0.4311 | 1 |
Echinococcus multilocularis | jun protein | 0.0085 | 0.4311 | 1 |
Brugia malayi | hypothetical protein | 0.0067 | 0.3059 | 0.7094 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0085 | 0.4311 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.3218 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0977 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0977 | 0.2265 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.1 | Inhibition of [3H]-mibolerone binding to cytosolic androgen receptor of rat ventral prostrate | ChEMBL. | 15715462 |
Log Ki (binding) | = 8.1 | Inhibition of [3H]-mibolerone binding to cytosolic androgen receptor of rat ventral prostrate | ChEMBL. | 15715462 |
Relative binding affinity (binding) | = 1.47 | Binding affinity against cytosolic androgen receptor from ventral prostate of rats using [3H]-MIB competitive binding assay (relative to dihydro testosterone) | ChEMBL. | 15239655 |
Relative binding affinity (binding) | = 1.47 | Binding affinity against cytosolic androgen receptor from ventral prostate of rats using [3H]-MIB competitive binding assay (relative to dihydro testosterone) | ChEMBL. | 15239655 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.