Detailed information for compound 21857

Basic information

Technical information
  • TDR Targets ID: 21857
  • Name: 7-(3-amino-2-methylazetidin-1-yl)-1-(2,4-difl uorophenyl)-6,8-difluoro-4-oxoquinoline-3-car boxylic acid
  • MW: 421.345 | Formula: C20H15F4N3O3
  • H donors: 2 H acceptors: 3 LogP: 1.12 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)n1cc(C(=O)O)c(=O)c2c1c(F)c(c(c2)F)N1CC(C1C)N
  • InChi: 1S/C20H15F4N3O3/c1-8-14(25)7-26(8)18-13(23)5-10-17(16(18)24)27(6-11(19(10)28)20(29)30)15-3-2-9(21)4-12(15)22/h2-6,8,14H,7,25H2,1H3,(H,29,30)
  • InChiKey: LTYHVZKKAHOLFU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-(3-amino-2-methyl-azetidin-1-yl)-1-(2,4-difluorophenyl)-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid
  • 7-(3-amino-2-methyl-1-azetidinyl)-1-(2,4-difluorophenyl)-6,8-difluoro-4-oxo-3-quinolinecarboxylic acid
  • 7-(3-azanyl-2-methyl-azetidin-1-yl)-1-(2,4-difluorophenyl)-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid
  • 7-(3-amino-2-methyl-azetidin-1-yl)-1-(2,4-difluorophenyl)-6,8-difluoro-4-keto-quinoline-3-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide receptor 0.0397 0.0563 0.0563
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0397 0.0563 0.0563
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.1656 0.3578 0.3578
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus multilocularis g protein coupled receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Brugia malayi putative neuropeptide receptor NPR1 0.0397 0.0563 0.0563
Echinococcus granulosus biogenic amine 5HT receptor 0.0397 0.0563 0.0563
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0368 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Schistosoma mansoni hypothetical protein 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Loa Loa (eye worm) melatonin receptor type 1A 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0397 0.0563 0.0563
Echinococcus granulosus tachykinin peptides receptor 99D 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0397 0.0563 0.0563
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0162 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Brugia malayi putative neuropeptide receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus granulosus neuropeptide FF receptor 2 0.0397 0.0563 0.0563
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0397 0.0563 1
Brugia malayi hypothetical protein 0.0397 0.0563 0.0563
Schistosoma mansoni opsin-like receptor 0.0397 0.0563 0.0563
Echinococcus granulosus neuropeptide receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Echinococcus granulosus orexin receptor type 2 0.0397 0.0563 0.0563
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0368 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.4338 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0397 0.0563 0.0563
Echinococcus granulosus 7tm_1 domain containing protein 0.0397 0.0563 0.0563
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0368 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Loa Loa (eye worm) protein-tyrosine phosphatase 0.4338 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0397 0.0563 0.0563
Schistosoma mansoni amine GPCR 0.0397 0.0563 0.0563
Echinococcus multilocularis neuropeptides capa receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Schistosoma mansoni hypothetical protein 0.0397 0.0563 0.0563
Echinococcus granulosus biogenic amine 5HT receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.1656 0.3578 0.3578
Onchocerca volvulus 0.0397 0.0563 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.4338 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0397 0.0563 0.0563
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus granulosus g-protein coupled receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0397 0.0563 0.0563
Onchocerca volvulus 0.0397 0.0563 1
Schistosoma mansoni neuropeptide receptor 0.0397 0.0563 0.0563
Schistosoma mansoni amine GPCR 0.0397 0.0563 0.0563
Schistosoma mansoni myosin xvIII 0.0397 0.0563 0.0563
Schistosoma mansoni amine GPCR 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0397 0.0563 0.0563
Echinococcus granulosus rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Echinococcus granulosus 7TM GPCR rhodopsin 0.0397 0.0563 0.0563
Brugia malayi larval opioid receptor 0.0397 0.0563 0.0563
Brugia malayi GnHR receptor homolog 0.0397 0.0563 0.0563
Echinococcus multilocularis G-protein coupled receptor, putative 0.0397 0.0563 0.0563
Brugia malayi follicle stimulating hormone receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis neuropeptide receptor 0.0397 0.0563 0.0563
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0397 0.0563 0.0563
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0315 0.0368 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0368 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0397 0.0563 0.0563
Onchocerca volvulus 0.0397 0.0563 1
Echinococcus granulosus neuropeptide Y receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis neuropeptide Y receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis g protein coupled receptor 0.0397 0.0563 0.0563
Brugia malayi hypothetical protein 0.0397 0.0563 0.0563
Echinococcus granulosus serotonin receptor 0.0397 0.0563 0.0563
Onchocerca volvulus 0.0397 0.0563 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) G-protein coupled receptor 0.0397 0.0563 0.0563
Brugia malayi Serotonin receptor 0.0397 0.0563 0.0563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0397 0.0563 0.0563
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0397 0.0563 0.0563
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0397 0.0563 0.0563
Schistosoma mansoni histamine h1 receptor 0.0397 0.0563 0.0563
Schistosoma mansoni growth hormone secretagogue receptor 0.0397 0.0563 0.0563
Echinococcus granulosus g protein coupled receptor 0.0397 0.0563 0.0563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0397 0.0563 0.0563
Echinococcus multilocularis neuropeptide FF receptor 2 0.0397 0.0563 0.0563
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0397 0.0563 0.0563
Echinococcus granulosus tm gpcr rhodopsin 0.0397 0.0563 0.0563
Echinococcus multilocularis rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Onchocerca volvulus 0.0397 0.0563 1
Onchocerca volvulus 0.0397 0.0563 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0397 0.0563 0.0563
Schistosoma mansoni opsin-like receptor 0.0397 0.0563 0.0563
Brugia malayi Dopamine receptor protein 1 0.0397 0.0563 0.0563
Loa Loa (eye worm) neuropeptide F receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) G-protein coupled receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Onchocerca volvulus 0.0397 0.0563 1
Echinococcus granulosus g protein coupled receptor 0.0397 0.0563 0.0563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0397 0.0563 0.0563
Brugia malayi G-protein coupled receptor 0.0397 0.0563 0.0563
Onchocerca volvulus Neuropeptide F receptor homolog 0.0397 0.0563 1
Echinococcus multilocularis G protein coupled receptor 139 0.0397 0.0563 0.0563
Treponema pallidum fructose-bisphosphate aldolase 0.0315 0.0368 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0397 0.0563 0.0563
Echinococcus multilocularis sex peptide receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis dro:myosuppressin receptor 0.0397 0.0563 0.0563
Schistosoma mansoni amine GPCR 0.0397 0.0563 0.0563
Onchocerca volvulus 0.0397 0.0563 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Echinococcus granulosus neuropeptides capa receptor 0.0397 0.0563 0.0563
Brugia malayi hypothetical protein 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Brugia malayi hypothetical protein 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.1656 0.3578 0.3578
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Onchocerca volvulus 0.0397 0.0563 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0397 0.0563 0.0563
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) TYRA-2 protein 0.0397 0.0563 0.0563
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0397 0.0563 0.0563
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0315 0.0368 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0397 0.0563 0.0563
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0397 0.0563 0.0563
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0397 0.0563 0.0563
Echinococcus multilocularis neuropeptide s receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0397 0.0563 0.0563
Echinococcus granulosus rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus granulosus rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Echinococcus granulosus neuropeptide receptor A26 0.0397 0.0563 0.0563
Echinococcus granulosus rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0162 0 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0368 1
Echinococcus granulosus tm gpcr rhodopsin 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0397 0.0563 0.0563
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.4338 1 1
Schistosoma mansoni biogenic amine receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0397 0.0563 0.0563
Echinococcus multilocularis g-protein coupled receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Echinococcus granulosus somatostatin receptor 0.0397 0.0563 0.0563
Brugia malayi Dopamine receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus multilocularis rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0397 0.0563 0.0563
Brugia malayi hypothetical protein 0.0397 0.0563 0.0563
Schistosoma mansoni adenoreceptor 0.0397 0.0563 0.0563
Echinococcus multilocularis orexin receptor type 2 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus granulosus neuropeptide receptor 0.0397 0.0563 0.0563
Schistosoma mansoni neuropeptide receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0397 0.0563 0.0563
Echinococcus multilocularis serotonin receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis fmrfamide receptor 0.0397 0.0563 0.0563
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0397 0.0563 0.0563
Echinococcus granulosus peptide allatostatin:somatostatin 0.0397 0.0563 0.0563
Schistosoma mansoni neuropeptide f receptor 76f 0.0397 0.0563 0.0563
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0162 0 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0397 0.0563 0.0563
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0162 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0397 0.0563 0.0563
Brugia malayi G protein-coupled receptor F59B2.13 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Onchocerca volvulus 0.0397 0.0563 1
Onchocerca volvulus 0.0397 0.0563 1
Echinococcus granulosus neuropeptide s receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Onchocerca volvulus 0.0397 0.0563 1
Brugia malayi hypothetical protein 0.0397 0.0563 0.0563
Echinococcus multilocularis rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Echinococcus granulosus alpha 1A adrenergic receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0368 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0397 0.0563 0.0563
Echinococcus granulosus hypothetical protein 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0397 0.0563 0.0563
Trypanosoma brucei protein tyrosine phosphatase 1 0.0162 0 0.5
Onchocerca volvulus 0.0397 0.0563 1
Schistosoma mansoni neuropeptide F-like receptor 0.0397 0.0563 0.0563
Schistosoma mansoni biogenic amine receptor 0.0397 0.0563 0.0563
Echinococcus granulosus fmrfamide receptor 0.0397 0.0563 0.0563
Echinococcus granulosus neuropeptide Y receptor 0.0397 0.0563 0.0563
Brugia malayi hypothetical protein 0.0397 0.0563 0.0563
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0397 0.0563 0.0563
Brugia malayi ORL1-like opioid receptor 0.0397 0.0563 0.0563
Echinococcus granulosus tm gpcr rhodopsin 0.0397 0.0563 0.0563
Brugia malayi neuropeptide F receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis serotonin receptor 0.0397 0.0563 0.0563
Leishmania major tyrosine specific protein phosphatase, putative 0.0162 0 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0397 0.0563 0.0563
Brugia malayi hypothetical protein 0.0397 0.0563 0.0563
Echinococcus multilocularis rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0368 1
Echinococcus multilocularis g protein coupled receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) neuropeptide F receptor 0.0397 0.0563 0.0563
Schistosoma mansoni amine GPCR 0.0397 0.0563 0.0563
Schistosoma mansoni opsin-like receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis allatostatin A receptor 0.0397 0.0563 0.0563
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0397 0.0563 0.0563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0397 0.0563 0.0563
Schistosoma mansoni biogenic amine receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0397 0.0563 0.0563
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis fmrfamide receptor 0.0397 0.0563 0.0563
Brugia malayi AKH receptor 0.0397 0.0563 0.0563
Brugia malayi G-protein coupled receptor 0.0397 0.0563 0.0563
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0397 0.0563 0.0563
Brugia malayi hypothetical protein 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Onchocerca volvulus 0.0397 0.0563 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Onchocerca volvulus 0.0397 0.0563 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus granulosus neuropeptides capa receptor 0.0397 0.0563 0.0563
Brugia malayi Tachykinin-like peptides receptor 99D 0.0397 0.0563 0.0563
Brugia malayi neuropeptide F receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Brugia malayi hypothetical protein 0.0397 0.0563 0.0563
Schistosoma mansoni hypothetical protein 0.0397 0.0563 0.0563
Echinococcus multilocularis neuropeptide receptor 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0397 0.0563 0.0563
Brugia malayi sulfakinin receptor protein 0.0397 0.0563 0.0563
Brugia malayi Melatonin receptor type 1A 0.0397 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0397 0.0563 0.0563
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0397 0.0563 0.0563
Echinococcus granulosus rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Brugia malayi RE15519p 0.0397 0.0563 0.0563
Schistosoma mansoni hypothetical protein 0.0397 0.0563 0.0563
Giardia lamblia Fructose-bisphosphate aldolase 0.0315 0.0368 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Echinococcus multilocularis somatostatin receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis neuropeptide Y receptor 0.0397 0.0563 0.0563
Echinococcus granulosus sex peptide receptor 0.0397 0.0563 0.0563
Schistosoma mansoni biogenic amine (5HT) receptor 0.0397 0.0563 0.0563
Schistosoma mansoni neuropeptide receptor 0.0397 0.0563 0.0563
Brugia malayi G protein-coupled receptor 0.0397 0.0563 0.0563
Echinococcus multilocularis neuropeptide receptor A26 0.0397 0.0563 0.0563
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0397 0.0563 0.0563
Schistosoma mansoni neuropeptide F-like receptor 0.0397 0.0563 0.0563
Onchocerca volvulus 0.0397 0.0563 1
Echinococcus granulosus allatostatin A receptor 0.0397 0.0563 0.0563
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0368 1
Onchocerca volvulus 0.0397 0.0563 1
Echinococcus granulosus G protein coupled receptor 139 0.0397 0.0563 0.0563
Brugia malayi Dopamine receptor protein 2 0.0397 0.0563 0.0563
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0397 0.0563 0.0563
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0397 0.0563 0.0563
Echinococcus multilocularis rhodopsin orphan GPCR 0.0397 0.0563 0.0563
Echinococcus granulosus g protein coupled receptor 0.0397 0.0563 0.0563
Brugia malayi Serotonin receptor 0.0397 0.0563 0.0563

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 2.3 mg kg-1 In vivo efficacy as ED50 against E. coli HM-42 by oral administration in mice. ChEMBL. 7707323
ED50 (functional) = 2.3 mg kg-1 In vivo efficacy as ED50 against E. coli HM-42 by oral administration in mice. ChEMBL. 7707323
ED50 (functional) = 10 mg kg-1 In vivo efficacy as ED50 against S. aureus HS-93 by oral administration in mice. ChEMBL. 7707323
ED50 (functional) = 61 mg kg-1 In vivo efficacy as ED50 against Pseudomonas aeruginosa HS-116 by oral administration in mice. ChEMBL. 7707323
MIC (functional) = 0.06 ug ml-1 In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Bacillus subtilis ATCC 6633(Bs). ChEMBL. 7707323
MIC (functional) = 0.06 ug ml-1 In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on klebsiella pneumoniae ATCC 10031 (Kp). ChEMBL. 7707323
MIC (functional) = 0.06 ug ml-1 In vitro antibacterial activity measured as minimum inhibitory concentration, was evaluated on Escherichia coli ATCC 23559(Ec). ChEMBL. 7707323
MIC (functional) = 0.06 ug ml-1 In vitro antibacterial activity measured as minimum inhibitory concentration, was evaluated on Enterobacter cloacae ATCC 23355 (Ecl). ChEMBL. 7707323
MIC (functional) = 0.06 ug ml-1 In vitro antibacterial activity measured as minimum inhibitory concentration, was evaluated on Escherichia coli ATCC 23559(Ec). ChEMBL. 7707323
MIC (functional) = 0.12 ug ml-1 In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Bacillus cereus ATCC 11778 (Bc). ChEMBL. 7707323
MIC (functional) = 0.12 ug ml-1 In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Staphylococcus aureus ATCC 25178 (Sa). ChEMBL. 7707323
MIC (functional) = 0.12 ug ml-1 In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Staphylococcus epidermidis ATCC 155-1 (Se). ChEMBL. 7707323
MIC (functional) = 0.12 ug ml-1 In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on morganella morganii ATCC 8019 (Mm). ChEMBL. 7707323
MIC (functional) = 0.5 ug ml-1 In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on proteus vulgaris ATCC 8427 (Pv). ChEMBL. 7707323
MIC (functional) = 1 ug ml-1 In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Streptococcus faecalis ATCC10541 (Sf). ChEMBL. 7707323
MIC (functional) = 1 ug ml-1 In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Pseudomonas aeruginosa ATCC 10145 (Pa). ChEMBL. 7707323

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.