Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate [NMDA] receptor subunit epsilon 2 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3B | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.0184 | 0.2828 | 0.2828 |
Onchocerca volvulus | Arrow homolog | 0.0122 | 0.0319 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0157 | 0.1747 | 0.1747 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0181 | 0.2702 | 0.2702 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0157 | 0.1747 | 0.1475 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0122 | 0.0319 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0157 | 0.1747 | 0.2933 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0181 | 0.2702 | 0.2702 |
Echinococcus multilocularis | fibrillin 1 | 0.0122 | 0.0319 | 0.0319 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0122 | 0.0319 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0162 | 0.1962 | 0.1962 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0181 | 0.2702 | 0.2702 |
Schistosoma mansoni | glutamate receptor kainate | 0.0162 | 0.1962 | 0.1698 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0162 | 0.1962 | 0.3374 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0162 | 0.1962 | 0.3374 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0181 | 0.2702 | 0.2702 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0162 | 0.1962 | 0.1698 |
Echinococcus granulosus | glutamate receptor 2 | 0.0181 | 0.2702 | 0.2702 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0162 | 0.1962 | 1 |
Echinococcus granulosus | laminin | 0.0122 | 0.0319 | 0.0319 |
Echinococcus granulosus | glutamate receptor 2 | 0.0115 | 0.0058 | 0.0058 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0162 | 0.1962 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0181 | 0.2702 | 0.2702 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0115 | 0.0058 | 0.0058 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0184 | 0.2828 | 0.2828 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.519 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0181 | 0.2702 | 0.2702 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0276 | 0.6529 | 0.6415 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0162 | 0.1962 | 0.1698 |
Schistosoma mansoni | glutamate receptor kainate | 0.0162 | 0.1962 | 0.1698 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0181 | 0.2702 | 0.2702 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0362 | 1 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0157 | 0.1747 | 0.1747 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0181 | 0.2702 | 0.2702 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0362 | 1 | 1 |
Echinococcus multilocularis | laminin | 0.0122 | 0.0319 | 0.0319 |
Schistosoma mansoni | glutamate receptor kainate | 0.0162 | 0.1962 | 0.1698 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0162 | 0.1962 | 0.1698 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1747 | 0.2933 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0181 | 0.2702 | 0.2702 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7 nM | Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain | ChEMBL. | 17290978 |
IC50 (binding) | = 7 nM | Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain | ChEMBL. | 17290978 |
IC50 (binding) | = 19 nM | Inhibition of [3H]-Ro-25-6981 binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 14552795 |
IC50 (functional) | = 19 nM | Inhibition of N-methyl-D-aspartate glutamate receptor-evoked increase of intracellular Ca+ in cells expressing NMDA glutamate receptor 1/2B | ChEMBL. | 14552795 |
IC50 (binding) | = 19 nM | Inhibition of [3H]-Ro-25-6981 binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 14552795 |
IC50 (functional) | = 19 nM | Inhibition of N-methyl-D-aspartate glutamate receptor-evoked increase of intracellular Ca+ in cells expressing NMDA glutamate receptor 1/2B | ChEMBL. | 14552795 |
IC50 (functional) | = 41 nM | Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium concentration | ChEMBL. | 17290978 |
IC50 (functional) | = 41 nM | Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium concentration | ChEMBL. | 17290978 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.