Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3B | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | References | |
Rattus norvegicus | Glutamate [NMDA] receptor subunit epsilon 2 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor kainate | 0.0162 | 0.1962 | 0.1698 |
Echinococcus granulosus | laminin | 0.0122 | 0.0319 | 0.0319 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0162 | 0.1962 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0184 | 0.2828 | 0.2828 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0162 | 0.1962 | 0.1698 |
Echinococcus granulosus | glutamate receptor 2 | 0.0115 | 0.0058 | 0.0058 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0162 | 0.1962 | 0.1962 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0362 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0181 | 0.2702 | 0.2702 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0122 | 0.0319 | 0.5 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0162 | 0.1962 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0181 | 0.2702 | 0.2702 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0162 | 0.1962 | 0.3374 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0162 | 0.1962 | 0.3374 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0181 | 0.2702 | 0.2702 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0157 | 0.1747 | 0.1475 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0162 | 0.1962 | 0.1698 |
Onchocerca volvulus | Arrow homolog | 0.0122 | 0.0319 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.519 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0157 | 0.1747 | 0.2933 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0157 | 0.1747 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1747 | 0.2933 |
Echinococcus granulosus | glutamate receptor 2 | 0.0181 | 0.2702 | 0.2702 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0181 | 0.2702 | 0.2702 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0181 | 0.2702 | 0.2702 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0181 | 0.2702 | 0.2702 |
Echinococcus granulosus | Tolloid protein 1 | 0.0157 | 0.1747 | 0.1747 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0184 | 0.2828 | 0.2828 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0362 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0276 | 0.6529 | 0.6415 |
Echinococcus multilocularis | fibrillin 1 | 0.0122 | 0.0319 | 0.0319 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0162 | 0.1962 | 0.1698 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0181 | 0.2702 | 0.2702 |
Schistosoma mansoni | glutamate receptor kainate | 0.0162 | 0.1962 | 0.1698 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0122 | 0.0319 | 0.5 |
Echinococcus multilocularis | laminin | 0.0122 | 0.0319 | 0.0319 |
Schistosoma mansoni | glutamate receptor kainate | 0.0162 | 0.1962 | 0.1698 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0115 | 0.0058 | 0.0058 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0181 | 0.2702 | 0.2702 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0181 | 0.2702 | 0.2702 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7 nM | Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain | ChEMBL. | 17290978 |
IC50 (binding) | = 7 nM | Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain | ChEMBL. | 17290978 |
IC50 (binding) | = 19 nM | Inhibition of [3H]-Ro-25-6981 binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 14552795 |
IC50 (functional) | = 19 nM | Inhibition of N-methyl-D-aspartate glutamate receptor-evoked increase of intracellular Ca+ in cells expressing NMDA glutamate receptor 1/2B | ChEMBL. | 14552795 |
IC50 (binding) | = 19 nM | Inhibition of [3H]-Ro-25-6981 binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 14552795 |
IC50 (functional) | = 19 nM | Inhibition of N-methyl-D-aspartate glutamate receptor-evoked increase of intracellular Ca+ in cells expressing NMDA glutamate receptor 1/2B | ChEMBL. | 14552795 |
IC50 (functional) | = 41 nM | Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium concentration | ChEMBL. | 17290978 |
IC50 (functional) | = 41 nM | Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium concentration | ChEMBL. | 17290978 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.