Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0075 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0075 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0075 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0075 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0075 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0075 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0075 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0075 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0075 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0075 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0075 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0075 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0075 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0075 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0075 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0075 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0075 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0075 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0075 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0075 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0075 | 0.5 | 0.5 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0075 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0075 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Antibacterial activity (functional) | = 0.39 | In vitro antibacterial activity against Escherichia coli NIHJ JC-2. | ChEMBL. | 11814802 |
Antibacterial activity (functional) | < 0.025 | In vitro antibacterial activity against Staphylococcus aureus 209P JC-1. | ChEMBL. | 11814802 |
Antibacterial activity (functional) | = 0.39 | In vitro antibacterial activity against Escherichia coli NIHJ JC-2. | ChEMBL. | 11814802 |
Antibacterial activity (functional) | = 0.78 | In vitro antibacterial activity against Ps. auruginosa 26. | ChEMBL. | 11814802 |
Antibacterial activity (functional) | = 3.13 | In vitro antibacterial activity against Proteus vulgaris IAM 1025. | ChEMBL. | 11814802 |
Antibacterial activity (functional) | = 25 | In vitro antibacterial activity against Staphylococcus aureus 3004 Methicillin-resistant S. aureus. | ChEMBL. | 11814802 |
Recovery (ADMET) | = 52 % | Tested for urinary recovery in mice after subcutaneous administration of 20 mg/Kg | ChEMBL. | 11814802 |
Recovery (ADMET) | = 52 % | Tested for urinary recovery in mice after subcutaneous administration of 20 mg/Kg | ChEMBL. | 11814802 |
Stability (functional) | Tested for stability of compound to human renal DHP-1 relative to imipenem (IMP); Not tested | ChEMBL. | 11814802 | |
Stability (functional) | = 0.13 | Tested for stability of compound to swine renal DHP-1 relative to imipenem (IMP) | ChEMBL. | 11814802 |
Stability (functional) | 0 | Tested for stability of compound to human renal DHP-1 relative to imipenem (IMP); Not tested | ChEMBL. | 11814802 |
Stability (functional) | = 0.13 | Tested for stability of compound to swine renal DHP-1 relative to imipenem (IMP) | ChEMBL. | 11814802 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.