Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histone deacetylase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | histone deacetylase 1, putative | 0.0077 | 0.052 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0077 | 0.052 | 0.052 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1079 | 1 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.0077 | 0.052 | 1 |
Echinococcus multilocularis | peroxidasin | 0.1079 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.1079 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.1079 | 1 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0077 | 0.052 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.1079 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.052 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.1079 | 1 | 1 |
Onchocerca volvulus | 0.1079 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Onchocerca volvulus | 0.1079 | 1 | 1 | |
Giardia lamblia | Histone deacetylase | 0.0077 | 0.052 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.1079 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.052 | 0.5 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0077 | 0.052 | 0.052 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.052 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.052 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1079 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.1079 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0077 | 0.052 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1079 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.1079 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0077 | 0.052 | 0.052 |
Brugia malayi | Animal haem peroxidase family protein | 0.1079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.052 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0077 | 0.052 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.052 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.052 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0077 | 0.052 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.1079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.1079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1079 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0077 | 0.052 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.052 | 0.052 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0077 | 0.052 | 0.052 |
Schistosoma mansoni | peroxidasin | 0.1079 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0077 | 0.052 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.0077 | 0.052 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.052 | 0.052 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.1079 | 1 | 1 |
Onchocerca volvulus | 0.1079 | 1 | 1 | |
Onchocerca volvulus | Peroxidase homolog | 0.1079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.052 | 0.5 |
Brugia malayi | Histone deacetylase 1 | 0.0077 | 0.052 | 0.052 |
Schistosoma mansoni | peroxidasin | 0.1079 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0077 | 0.052 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.1079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0077 | 0.052 | 1 |
Echinococcus granulosus | peroxidasin | 0.1079 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.052 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.052 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0077 | 0.052 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0077 | 0.052 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0077 | 0.052 | 0.052 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 21 nM | Inhibitory activity against histone deacetylase (HDAC1 and HDAC2) isolated from K562 erythroleukemia cells | ChEMBL. | 14552787 |
IC50 (binding) | = 21 nM | Inhibitory activity against histone deacetylase (HDAC1 and HDAC2) isolated from K562 erythroleukemia cells | ChEMBL. | 14552787 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.