Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | p450 reductase, putative | 0.0101 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0101 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0101 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0101 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0101 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0101 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0089 | 0.7743 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.005 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0062 | 0.2407 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0101 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0101 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0101 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0101 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0101 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0101 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0101 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0101 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0101 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0101 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0089 | 0.7743 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.005 | 0 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0101 | 1 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0051 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0101 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0101 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0062 | 0.2407 | 0.2407 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0101 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0101 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
HDL-C (functional) | = 50.7 mg dl-1 | Hypolipidemic effects of compound on rat plasma high density lipoprotein cholesterol (HDLC) level after peroral administration at 100 mg/kg dose | ChEMBL. | 3163736 |
Liver weight (functional) | = 54.6 mg (g of body weight)-1 | Hypolipidemic effects in rat fed a normal diet by peroral administration at 100 mg/kg dose(increase in liver weight with respect to body weight mg/g) | ChEMBL. | 3163736 |
Liver weight (functional) | = 67.1 mg (g of body weight)-1 | Hypolipidemic effects in rat fed a high cholesterol diet (HC) by peroral administration at 100 mg/kg dose(increase in liver weight with respect to body weight mg/g) | ChEMBL. | 3163736 |
TC (functional) | = 194.6 mg dl-1 | Hypolipidemic effect on rat plasma Total cholesterol (TC) level by peroral administration at 100 mg/kg dose | ChEMBL. | 3163736 |
TG (functional) | = 41.3 mg dl-1 | Hypolipidemic effects of compound on rat plasma Triglyceride (TG) level after peroral administration at 100 mg/kg dose | ChEMBL. | 3163736 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.