Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0327 | 0.4015 | 0.4015 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.2061 | 1 |
Echinococcus multilocularis | geminin | 0.0183 | 0.2061 | 1 |
Loa Loa (eye worm) | p25-alpha family protein | 0.0768 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0105 | 0.0999 | 0.0999 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.2061 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.0547 | 0.0547 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0021 | 0.0103 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0547 | 0.2652 |
Onchocerca volvulus | 0.0327 | 0.4015 | 0.4015 | |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0021 | 0.0103 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0242 | 0.0242 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0021 | 0.0103 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0105 | 0.0999 | 0.0999 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0242 | 0.1172 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0021 | 0.0103 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0021 | 0.0103 |
Onchocerca volvulus | TPPP family protein homolog | 0.0768 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0021 | 0.0021 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0242 | 0.1172 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0242 | 0.1172 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.4015 | 0.4015 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0242 | 0.1172 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0021 | 0.0103 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0242 | 0.0242 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0021 | 0.0103 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0999 | 0.0999 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0242 | 0.1172 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0242 | 0.1172 |
Echinococcus granulosus | geminin | 0.0183 | 0.2061 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0242 | 0.1172 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0547 | 0.0547 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0021 | 0.0103 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0105 | 0.0999 | 0.0999 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0021 | 0.0103 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0021 | 0.0103 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.003 uM | Tested for inhibition against Prostaglandin G/H synthase 2 | ChEMBL. | 7966148 |
IC50 (binding) | = 0.003 uM | In vitro inhibition of prostaglandin G/H synthase 2 (COX-2). | ChEMBL. | 7473585 |
IC50 (binding) | = 0.003 uM | Tested for inhibition against Prostaglandin G/H synthase 2 | ChEMBL. | 7966148 |
IC50 (binding) | = 0.003 uM | In vitro inhibition of prostaglandin G/H synthase 2 (COX-2). | ChEMBL. | 7473585 |
IC50 (binding) | > 100 uM | Tested for inhibition against Prostaglandin G/H synthase 1 | ChEMBL. | 7966148 |
IC50 (binding) | > 100 uM | In vitro inhibition of prostaglandin G/H synthase 1. | ChEMBL. | 7473585 |
IC50 (binding) | > 100 uM | Tested for inhibition against Prostaglandin G/H synthase 1 | ChEMBL. | 7966148 |
IC50 (binding) | > 100 uM | In vitro inhibition of prostaglandin G/H synthase 1. | ChEMBL. | 7473585 |
Selectivity (binding) | > 33000 | Ratio of IC50 for COX-1 and COX-2 binding inhibitors | ChEMBL. | 7966148 |
Selectivity (binding) | > 33000 | Ratio of IC50 of COX-1 to COX-2. | ChEMBL. | 7473585 |
Selectivity (binding) | > 33000 | Ratio of IC50 for COX-1 and COX-2 binding inhibitors | ChEMBL. | 7966148 |
Selectivity (binding) | > 33000 | Ratio of IC50 of COX-1 to COX-2. | ChEMBL. | 7473585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.