Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0239 | 0.3495 | 0.2496 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0278 | 0.4208 | 0.4208 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0186 | 0.2511 | 0.1661 |
Loa Loa (eye worm) | sodium/potassium-transporting ATPase subunit alpha | 0.0105 | 0.1019 | 0.0572 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0239 | 0.3495 | 0.2496 |
Schistosoma mansoni | Na+/K+ transporting ATPase subunit alpha | 0.0122 | 0.133 | 0.133 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0591 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0591 | 1 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0339 | 0.5331 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0591 | 1 | 0.5 |
Echinococcus multilocularis | nervana 2 | 0.0239 | 0.3495 | 0.2496 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0278 | 0.4208 | 0.3551 |
Loa Loa (eye worm) | matrixin family protein | 0.0339 | 0.5331 | 0.5099 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0278 | 0.4208 | 0.392 |
Loa Loa (eye worm) | Na,K-ATPase alpha subunit | 0.0122 | 0.133 | 0.0899 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.2511 | 0.2139 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1896 | 0.1493 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0198 | 0.2731 | 0.1616 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0153 | 0.1896 | 0.1896 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.0198 | 0.2731 | 0.2731 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0278 | 0.4208 | 0.3551 |
Echinococcus granulosus | carbonic anhydrase | 0.0278 | 0.4208 | 0.3319 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0555 | 0.933 | 0.9227 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0278 | 0.4208 | 0.4208 |
Toxoplasma gondii | hypothetical protein | 0.0278 | 0.4208 | 0.5 |
Echinococcus multilocularis | nervana 2 | 0.0198 | 0.2731 | 0.1616 |
Leishmania major | carbonic anhydrase-like protein | 0.0591 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0278 | 0.4208 | 0.3319 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1896 | 0.1493 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0591 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0827 | 0.0371 |
Echinococcus multilocularis | carbonic anhydrase | 0.0278 | 0.4208 | 0.3319 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0278 | 0.4208 | 0.3551 |
Onchocerca volvulus | 0.0239 | 0.3495 | 0.5499 | |
Echinococcus multilocularis | carbonic anhydrase II | 0.0591 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0278 | 0.4208 | 0.4208 |
Echinococcus multilocularis | nervana 2 | 0.0198 | 0.2731 | 0.1616 |
Brugia malayi | Hemopexin family protein | 0.0216 | 0.3075 | 0.2289 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.3495 | 0.3171 |
Mycobacterium ulcerans | hydrolase | 0.0186 | 0.2511 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0278 | 0.4208 | 0.3551 |
Echinococcus granulosus | carbonic anhydrase | 0.0278 | 0.4208 | 0.3319 |
Onchocerca volvulus | 0.0153 | 0.1896 | 0.1582 | |
Echinococcus granulosus | nervana 2 | 0.0239 | 0.3495 | 0.2496 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0153 | 0.1896 | 0.1493 |
Onchocerca volvulus | Matrilysin homolog | 0.0339 | 0.5331 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0591 | 1 | 1 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0198 | 0.2731 | 0.2731 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0555 | 0.933 | 0.9227 |
Schistosoma mansoni | carbonic anhydrase | 0.0278 | 0.4208 | 0.4208 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1896 | 0.1493 |
Echinococcus multilocularis | carbonic anhydrase | 0.0278 | 0.4208 | 0.3319 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0239 | 0.3495 | 0.2496 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0586 | 0.0118 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0239 | 0.3495 | 0.2496 |
Plasmodium falciparum | carbonic anhydrase | 0.0278 | 0.4208 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0153 | 0.1896 | 0.0977 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0278 | 0.4208 | 0.3551 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0239 | 0.3495 | 0.3495 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.4208 | 0.392 |
Brugia malayi | Matrixin family protein | 0.0153 | 0.1896 | 0.0977 |
Brugia malayi | Na,K-ATPase alpha subunit | 0.0122 | 0.133 | 0.0347 |
Brugia malayi | Matrixin family protein | 0.0369 | 0.5895 | 0.5429 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0186 | 0.2511 | 0.5 |
Echinococcus granulosus | nervana 2 | 0.0239 | 0.3495 | 0.2496 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0239 | 0.3495 | 0.2496 |
Echinococcus granulosus | nervana 2 | 0.0198 | 0.2731 | 0.1616 |
Onchocerca volvulus | Matrilysin homolog | 0.0153 | 0.1896 | 0.1582 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0198 | 0.2731 | 0.1616 |
Echinococcus granulosus | nervana 2 | 0.0198 | 0.2731 | 0.1616 |
Loa Loa (eye worm) | matrixin family protein | 0.0369 | 0.5895 | 0.5691 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.3495 | 0.3171 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0239 | 0.3495 | 0.2496 |
Schistosoma mansoni | hypothetical protein | 0.0216 | 0.3075 | 0.3075 |
Schistosoma mansoni | na+/k+ atpase alpha subunit | 0.0122 | 0.133 | 0.133 |
Onchocerca volvulus | 0.0198 | 0.2731 | 0.3627 | |
Brugia malayi | Matrixin family protein | 0.0153 | 0.1896 | 0.0977 |
Giardia lamblia | Potassium-transporting ATPase alpha chain 1 | 0.0122 | 0.133 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0278 | 0.4208 | 0.4208 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0186 | 0.2511 | 1 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0239 | 0.3495 | 0.3495 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0591 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0278 | 0.4208 | 0.3319 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0591 | 1 | 1 |
Schistosoma mansoni | transmemberane protein | 0.0239 | 0.3495 | 0.3495 |
Brugia malayi | Matrixin family protein | 0.0153 | 0.1896 | 0.0977 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0591 | 1 | 1 |
Onchocerca volvulus | 0.0216 | 0.3075 | 0.447 | |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.4208 | 0.392 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0591 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.133 | 0.0899 |
Echinococcus multilocularis | nervana 2 | 0.0239 | 0.3495 | 0.2496 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.4208 | 0.392 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.